Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-10-22 |
タイトル |
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タイトル |
Add-On Effect of Angiotensin Receptor Blockade (Candesartan) on Clinical Remission in Active IgA Nephropathy Patients Treated with Steroid Pulse Therapy and Tonsillectomy: a Randomized, Parallel-Group Comparison Trial |
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言語 |
en |
作成者 |
Kohagura, Kentaro
Arima, Hisatomi
Miyasato, Hitoshi
Chang, Tung-Huei
Yamazato, Masanobu
Kobori, Hiroyuki
Nishiyama, Akira
Iseki, Kunitoshi
Ohya, Yusuke
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Angiotensin receptor inhibitor |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Clinical remission |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
IgA nephropathy |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Steroid pulse therapy |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Tonsillectomy |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Background/Aims: Angiotensin receptor blockers (ARBs) may be beneficial for clinical remission during conventional therapy with tonsillectomy and steroid pulse (TSP) for active IgA nephropathy. Methods: Seventy-seven patients with active IgA nephropathy were randomly assigned to the control arm with conventional regimen (TSP followed by oral prednisolone) (n = 37) or the ARB arm with conventional regimen plus ARB candesartan for the first 6 months (n = 40). Patients not achieving proteinuria remission at 12 months in either arm were administered candesartan, which was titrated until the 24-month follow-up. The primary endpoints were remission of proteinuria (< 0.3 g/gCr) and hematuria at 12 months. Results: Baseline proteinuria (g/g Cr) were comparable between the control and ARB arm (1.02 vs. 0.97, P = 0.97). Similarly, cumulative remission rates at 6, 12, and 24 months were comparable between the control and ARB arms (37.8% vs. 35% [P = 0.80], 48.7% vs. 38.5% [P = 0.37], 71.4% vs. 51.3% [P = 0.08]). Proteinuria, which was slightly worse in the control arm than in the ARB arm at 6 months, was comparable afterwards (0.20 vs. 0.23 g/g Cr at 12 months; 0.12 vs. 0.13 g/g Cr at 24 months). Significant reductions observed in urinary angiotensinogen were almost comparable between the two treatment arms at both 6 and 12 months. Conclusion: Early candesartan treatment combined with TSP may not benefit clinical remission regardless of the blood pressure. ARB titration later during the treatment might provide benefit for patients with active IgA nephropathy. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
Karger |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/47078 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1159/000489914 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1159/000489914 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1420-4096 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1423-0143 |
収録物名 |
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言語 |
en |
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収録物名 |
Kidney and Blood Pressure Research |
書誌情報 |
巻 43,
号 3,
p. 780-792,
発行日 2018-05-22
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