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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells

http://hdl.handle.net/20.500.12000/47186
http://hdl.handle.net/20.500.12000/47186
40fa4dfb-ed5d-4fb3-a009-8a2f1759a175
名前 / ファイル ライセンス アクション
1-s2.0-S134786131730052X-main.pdf 1-s2.0-S134786131730052X-main.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-11-11
タイトル
タイトル Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells
言語 en
作成者 Li, Xiaojia

× Li, Xiaojia

en Li, Xiaojia

Horishita, Takafumi

× Horishita, Takafumi

en Horishita, Takafumi

Toyohira, Yumiko

× Toyohira, Yumiko

en Toyohira, Yumiko

Shao, Hui

× Shao, Hui

en Shao, Hui

Bai, Jie

× Bai, Jie

en Bai, Jie

Bo, Haixia

× Bo, Haixia

en Bo, Haixia

Song, Xinbo

× Song, Xinbo

en Song, Xinbo

Ishikane, Shin

× Ishikane, Shin

en Ishikane, Shin

Yoshinaga, Yukari

× Yoshinaga, Yukari

en Yoshinaga, Yukari

Satoh, Noriaki

× Satoh, Noriaki

en Satoh, Noriaki

Tsutsui, Masato

× Tsutsui, Masato

en Tsutsui, Masato

Yanagihara, Nobuyuki

× Yanagihara, Nobuyuki

en Yanagihara, Nobuyuki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述タイプ Other
内容記述 Extract of pine nodules (matsufushi) formed by bark proliferation on the surface of trees of Pinus tabulaeformis or Pinus massoniana has been used as an analgesic for joint pain, rheumatism, neuralgia, dysmenorrhea and other complaints in Chinese traditional medicine. Here we report the effects of matsufushi extract and its components on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. We found that matsufushi extract (0.0003–0.005%) and its component, SJ-2 (5-hydroxy-3-methoxy-trans-stilbene) (0.3–100 μM), but not the other three, concentration-dependently inhibited catecholamine secretion induced by acetylcholine, a physiological secretagogue. Matsufushi extract (0.0003–0.005%) and SJ-2 (0.3–100 μM) also inhibited ^<45>Ca^<2+> influx induced by acetylcholine in a concentration-dependent manner, similar to its effect on catecholamine secretion. They also suppressed 14C-catecholamine synthesis and tyrosine hydroxylase activity induced by acetylcholine. In Xenopus oocytes expressing α3β4 nicotinic acetylcholine receptors, matsufushi extract (0.00003–0.001%) and SJ-2 (1–100 μM) directly inhibited the current evoked by acetylcholine. The present findings suggest that SJ-2, as well as matsufushi extract, inhibits acetylcholine-induced catecholamine secretion and synthesis by suppression of nicotinic acetylcholine receptor-ion channels in bovine adrenal medullary cells.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47186
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jphs.2017.03.006
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jphs.2017.03.006
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-8613
収録物識別子タイプ ISSN
収録物識別子 1347-8648
収録物名
言語 en
収録物名 Journal of Pharmacological Sciences
書誌情報
巻 133, 号 4, p. 268-275
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