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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL

http://hdl.handle.net/20.500.12000/47233
http://hdl.handle.net/20.500.12000/47233
c030b311-1d77-4bfa-9ee3-a323021a2013
名前 / ファイル ライセンス アクション
advancesadv2019001429.pdf advancesadv2019001429.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-11-16
タイトル
タイトル Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
言語 en
作成者 Guerrero, Carmina Louise Hugo

× Guerrero, Carmina Louise Hugo

en Guerrero, Carmina Louise Hugo

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Yamashita, Yoshiko

× Yamashita, Yoshiko

en Yamashita, Yoshiko

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Miyara, Megumi

× Miyara, Megumi

en Miyara, Megumi

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Imaizumi, Naoki

× Imaizumi, Naoki

en Imaizumi, Naoki

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Kato, Megumi

× Kato, Megumi

en Kato, Megumi

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Sakihama, Shugo

× Sakihama, Shugo

en Sakihama, Shugo

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Hayashi, Masaki

× Hayashi, Masaki

en Hayashi, Masaki

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Miyagi, Takashi

× Miyagi, Takashi

en Miyagi, Takashi

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Karimata, Kaori

× Karimata, Kaori

en Karimata, Kaori

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Uchihara, Junnosuke

× Uchihara, Junnosuke

en Uchihara, Junnosuke

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Ohshiro, Kazuiku

× Ohshiro, Kazuiku

en Ohshiro, Kazuiku

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Todoroki, Junpei

× Todoroki, Junpei

en Todoroki, Junpei

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Nakachi, Sawako

× Nakachi, Sawako

en Nakachi, Sawako

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Morishima, Satoko

× Morishima, Satoko

en Morishima, Satoko

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Karube, Kennosuke

× Karube, Kennosuke

en Karube, Kennosuke

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Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

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Masuzaki, Hiroaki

× Masuzaki, Hiroaki

en Masuzaki, Hiroaki

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Fukushima, Takuya

× Fukushima, Takuya

en Fukushima, Takuya

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © 2020 by The American Society of Hematology
内容記述
内容記述タイプ Other
内容記述 Adult T-cell leukemia/lymphoma (ATL) is a human T-cell leukemia virus type 1 (HTLV-1)–associated T-cell malignancy with generally poor prognosis. Although only ∼5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. In this study, we analyzed blood plasma profiles of asymptomatic HTLV-1 carriers (ACs); untreated ATL patients, including acute, lymphoma, smoldering, and chronic types; and ATL patients in remission. Through SOMAscan, expression levels of 1305 plasma proteins were analyzed in 85 samples (AC, n = 40; ATL, n = 40; remission, n = 5). Using gene set enrichment analysis and gene ontology, overrepresented pathways in ATL vs AC included angiogenesis, inflammation by cytokines and chemokines, interleukin-6 (IL-6)/JAK/STAT3, and notch signaling. In selecting candidate biomarkers, we focused on soluble tumor necrosis factor receptor 2 (sTNFR2) because of its active role in enriched pathways, extreme significance (Welch’s t test P < .00001), high discrimination capacity (area under the curve >0.90), and novelty in ATL research. Quantification of sTNFR2 in 102 plasma samples (AC, n = 30; ATL, n = 68; remission, n = 4) using enzyme-linked immunosorbent assay showed remarkable elevations in acute ATL, at least 10 times those of AC samples, and return of sTNFR2 to AC state levels after achieving remission. Flow cytometry and immunostaining validated the expression of TNFR2 in ATL cells. No correlation between sIL-2 and sTNFR2 levels in acute ATL was found, suggesting the possibility of sTNFR2 as an independent biomarker. Our findings represent the first extensive blood-based proteomic analysis of ATL, suggesting the potential clinical utility of sTNFR2 in diagnosing acute ATL.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 American Society of Hematology
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47233
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1182/bloodadvances.2019001429
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1182/bloodadvances.2019001429
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2473-9529
収録物名
言語 en
収録物名 Blood Advances
書誌情報
巻 4, 号 6, p. 1062-1071, 発行日 2020-03-24
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