Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-11-16 |
タイトル |
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タイトル |
Effectiveness of Subcutaneous Growth Hormone in HIV-1 Patients with Moderate to Severe Facial Lipoatrophy |
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言語 |
en |
作成者 |
Honda, Miwako
Yogi, Akira
Ishizuka, Naoki
Genka, Ikumi
Gatanaga, Hiroyuki
Teruya, Katsuji
Tachikawa, Natsuo
Kikuchi, Yoshimi
Oka, Shinichi
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
HIV |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
antiretroviral treatment |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
lipoatrophy |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
recombinant human growth hormone |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Objective: To evaluate effect of recombinant human growth hormone (rhGH) among HIV-infected adults with moderate to severe facial lipoatrophy as a side effect of long-term antiretroviral treatment.\nDesign: A prospective open-label study\nMethods: Twenty-five HIV-1 patients with moderate to severe facial lipoatrophy who had been on antiretroviral treatment for more than 18 months were enrolled. rhGH (5 mg) was given every other day for 6 months. After treatment was completed, the participants were followed up for 6 months. Facial lipoatrophy was evaluated by computed tomography at months 0, 3, 6 and 12.\nResults: Nearly all participants (24 of 25) completed the study. The sum of bilateral soft tissue thickness at the level of zygomatics at months 0, 3, 6, 12 were 7.23, 8.59, 8.35, 8.60 mm, respectively. There was significant improvement from baseline in month 3 (p=0.009) and month 12 (p=0.021). In the 6 months of follow-up, the soft tissue showed no significant decrease. Several side effects including diarrhea, arthralgia, myalgia, mastalgia and hand numbness were seen, which were self-limited and transient.\nConclusion: rhGH is effective and relatively safe for moderate to severe facial lipoatrophy. Its effect was sustained at least for 6 months after the cessation of rhGH. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
The Japanese Society of Internal Medicine |
出版者 |
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言語 |
ja |
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出版者 |
一般社団法人 日本内科学会 |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/47242 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.2169/internalmedicine.46.6122 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.2169/internalmedicine.46.6122 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1349-7235 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0918-2918 |
収録物名 |
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言語 |
en |
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収録物名 |
Internal Medicine |
書誌情報 |
巻 46,
号 7,
p. 359-362,
発行日 2007
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