| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2020-12-15 |
| タイトル |
|
|
タイトル |
Impact of the one‐carbon metabolism on oocyte maturation, fertilization, embryo quality, and subsequent pregnancy |
|
言語 |
ja |
| 作成者 |
Akamine, Kozue
Mekaru, Keiko
Gibo, Keiya
Nagata, Chinatsu
Nakamura, Rie
Oishi, Sugiko
Miyagi, Maho
Heshiki, Chiaki
Aoki, Yoichi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
clinical pregnancy |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
embryo quality |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
folic acid |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
homocysteine |
| 主題 |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
one‐carbon metabolism |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Purpose: To investigate impact of the one‐carbon metabolism (OCM) on oocyte maturity and embryo development.\nMethods: This prospective study analyzed 18 women who agreed to participate. We measured the OCM biomarkers’ concentrations including Vitamin B12 (VB12), folic acid (FA), and homocysteine (Hcy) in serum and follicular fluid (FF), and assessed their correlation. We also evaluated the influence of such OCM biomarker concentrations in mono‐FF on oocyte maturation, fertilization, embryo quality, and consequent pregnancy after embryo transfers.\nResults: All biomarkers showed a high concentration variability in different follicles of each woman, but their mean levels correlated with the serum levels. Among the 106 collected oocytes, 92 were mature, 59 were fertilized, and 16 yielded good‐quality embryos. We performed 26 single embryo transfers, and 7 patients achieved clinical pregnancies. VB12 concentration (FF) was significantly lower in fertilized than unfertilized oocytes by univariate analysis. In multivariate logistic analysis, a significant correlation was found between FA concentration (FF) <14.25 ng/mL and good‐quality embryos and between Hcy concentration (FF) <4.9 nmol/mL and clinical pregnancy.\nConclusion: OCM in FF may affect fertilization, embryo quality, and clinical pregnancy. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
|
|
識別子 |
http://hdl.handle.net/20.500.12000/47491 |
|
識別子タイプ |
HDL |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/rmb2.12354 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/rmb2.12354 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1445-5781 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1447-0578 |
| 収録物名 |
|
|
収録物名 |
Reproductive Medicine and Biology |
|
言語 |
en |
| 書誌情報 |
発行日 2020-10-25
|
rmb2.12354.pdf
