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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages

http://hdl.handle.net/20.500.12000/47485
http://hdl.handle.net/20.500.12000/47485
bd81a9d2-cd13-4699-8c24-8776507ed48f
名前 / ファイル ライセンス アクション
Toma Toma et al. 2014_ for UR.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-15
タイトル
タイトル Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages
言語 en
作成者 Toma, Claudia

× Toma, Claudia

en Toma, Claudia

Murray, Gerald L.

× Murray, Gerald L.

en Murray, Gerald L.

Nohara, Toshitsugu

× Nohara, Toshitsugu

en Nohara, Toshitsugu

Mizuyama, Masaru

× Mizuyama, Masaru

en Mizuyama, Masaru

Koizumi, Nobuo

× Koizumi, Nobuo

en Koizumi, Nobuo

Adler, Ben

× Adler, Ben

en Adler, Ben

Suzuki, Toshihiko

× Suzuki, Toshihiko

en Suzuki, Toshihiko

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
内容記述
内容記述タイプ Other
内容記述 Leptospira interrogans is responsible for the zoonotic disease leptospirosis. The pathogenic mechanisms of this spirochaete remain poorly understood; however, virulence has been correlated with increased phagocytic uptake and survival within macrophages. Leptospiral outer membrane proteins are thought to be responsible for persistence in vivo via interaction with specific host components. In this study, we analysed the transcriptional profile of a virulent strain and its culture‐attenuated derivative strain to identify bacterial factors that may be involved in pathogenesis. Two outer membrane proteins, LMB216 and LigB (leptospiral immunoglobulin‐like protein B) were downregulated more than 10‐fold in the culture‐attenuated strain. We show that both proteins play a role in leptospiral uptake by macrophages and that LMB216, as well as LigB, enhances the binding of leptospires to fibronectin. Taken together, our results indicate that LMB216 plays a role in pathogen interaction with host molecule/s, which may contribute to pathogenesis of leptospirosis.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/47485
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cmi.12296
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cmi.12296
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1462-5822
収録物識別子タイプ ISSN
収録物識別子 1462-5814
収録物名
言語 en
収録物名 Cellular Microbiology
書誌情報
巻 16, 号 9, p. 1366-1377
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