Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-12-15 |
タイトル |
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タイトル |
Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages |
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言語 |
en |
作成者 |
Toma, Claudia
Murray, Gerald L.
Nohara, Toshitsugu
Mizuyama, Masaru
Koizumi, Nobuo
Adler, Ben
Suzuki, Toshihiko
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Leptospira interrogans is responsible for the zoonotic disease leptospirosis. The pathogenic mechanisms of this spirochaete remain poorly understood; however, virulence has been correlated with increased phagocytic uptake and survival within macrophages. Leptospiral outer membrane proteins are thought to be responsible for persistence in vivo via interaction with specific host components. In this study, we analysed the transcriptional profile of a virulent strain and its culture‐attenuated derivative strain to identify bacterial factors that may be involved in pathogenesis. Two outer membrane proteins, LMB216 and LigB (leptospiral immunoglobulin‐like protein B) were downregulated more than 10‐fold in the culture‐attenuated strain. We show that both proteins play a role in leptospiral uptake by macrophages and that LMB216, as well as LigB, enhances the binding of leptospires to fibronectin. Taken together, our results indicate that LMB216 plays a role in pathogen interaction with host molecule/s, which may contribute to pathogenesis of leptospirosis. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
Wiley |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/47485 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1111/cmi.12296 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1111/cmi.12296 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1462-5822 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1462-5814 |
収録物名 |
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言語 |
en |
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収録物名 |
Cellular Microbiology |
書誌情報 |
巻 16,
号 9,
p. 1366-1377,
発行日 2014-09
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