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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Urine Lactoferrin as a Potential Biomarker Reflecting the Degree of Malignancy in Urothelial Carcinoma of the Bladder

http://hdl.handle.net/20.500.12000/47509
http://hdl.handle.net/20.500.12000/47509
b84419db-b442-4d25-906e-148664fca7fb
名前 / ファイル ライセンス アクション
252_225.pdf 252_225.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-16
タイトル
タイトル Urine Lactoferrin as a Potential Biomarker Reflecting the Degree of Malignancy in Urothelial Carcinoma of the Bladder
言語 en
作成者 Matsumura, Eri

× Matsumura, Eri

en Matsumura, Eri

Kosuge, Noritake

× Kosuge, Noritake

en Kosuge, Noritake

Nakanishi, Shotaro

× Nakanishi, Shotaro

en Nakanishi, Shotaro

Suda, Tetsuji

× Suda, Tetsuji

en Suda, Tetsuji

Sugawa, Ai

× Sugawa, Ai

en Sugawa, Ai

Fujimura, Tsutomu

× Fujimura, Tsutomu

en Fujimura, Tsutomu

Miyagi, Ryota

× Miyagi, Ryota

en Miyagi, Ryota

Yoshimi, Naoki

× Yoshimi, Naoki

en Yoshimi, Naoki

Saito, Seiichi

× Saito, Seiichi

en Saito, Seiichi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 degree of malignancy
言語 en
主題Scheme Other
主題 lactoferrin
言語 en
主題Scheme Other
主題 tumor-infiltrating neutrophils
言語 en
主題Scheme Other
主題 urine biomarker
言語 en
主題Scheme Other
主題 urothelial carcinoma of the bladder
内容記述
内容記述タイプ Other
内容記述 Urothelial carcinoma of the bladder (UCB) is potentially life-threatening; therefore, we aimed to discover a novel urine biomarker for diagnosis and prognostication of UCB. This is a retrospective case-control study. Exploration of a new biomarker using urine from 20 UCB patients in the present study revealed that urinary level of lactoferrin (LF), a multifunctional glycoprotein released from neutrophils, was higher in 11 of 15 with invasive/high-grade UCB than 5 with non-invasive one, and 2 healthy adults. We therefore focused on LF and assessed the value of urine LF normalized by urine creatinine concentration (LF/Cr) using an enzyme-linked immunosorbent assay. Diagnostic performance of urine LF/Cr was examined using urine from 92 patients with primary (newly diagnosed) untreated UCB and 166 controls without UCB, including 62 patients with pyuria, and 104 subjects without pyuria consisting of 84 patients and 20 healthy adults. However, the diagnostic accuracies were accompanied by the risk of bias. In 92 primary UCB patients, both pyuria and tumor-infiltrating neutrophils (TINs) were independent predictors for urine LF/Cr. In contrast, TINs or urine LF/Cr were independent predictors for invasive histology, whereas pyuria was not. In terms of prognostication, urine LF/Cr and nodal metastasis were independent predictors of disease-specific survival in 22 patients with muscle-invasive bladder cancer, characterized by a high mortality rate, in the Cox proportional hazards model. In conclusion, urine LF/Cr linked to TINs was a predictor of both invasive histology and prognosis in UCB. Urine LF/Cr is a potential biomarker reflecting the degree of malignancy in UCB.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Tohoku University Medical Press
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47509
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1620/tjem.252.225
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1620/tjem.252.225
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-3329
収録物識別子タイプ ISSN
収録物識別子 0040-8727
収録物名
言語 en
収録物名 The Tohoku Journal of Experimental Medicine
書誌情報
巻 252, 号 3, p. 225-244
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