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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model

http://hdl.handle.net/20.500.12000/47548
http://hdl.handle.net/20.500.12000/47548
e878ceb7-07a7-4683-b518-dee6d4fec5e7
名前 / ファイル ライセンス アクション
Kiyuna2018_Article_TrabectedinArrestsADoxorubicin.pdf Kiyuna2018_Article_TrabectedinArrestsADoxorubicin.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-21
タイトル
タイトル Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model
言語 en
作成者 Kiyuna, Tasuku

× Kiyuna, Tasuku

en Kiyuna, Tasuku

Tome, Yasunori

× Tome, Yasunori

en Tome, Yasunori

Murakami, Takashi

× Murakami, Takashi

en Murakami, Takashi

Kawaguchi, Kei

× Kawaguchi, Kei

en Kawaguchi, Kei

Igarashi, Kentaro

× Igarashi, Kentaro

en Igarashi, Kentaro

Miyake, Kentaro

× Miyake, Kentaro

en Miyake, Kentaro

Miyake, Masuyo

× Miyake, Masuyo

en Miyake, Masuyo

Li, Yunfeng

× Li, Yunfeng

en Li, Yunfeng

Nelson, Scott D.

× Nelson, Scott D.

en Nelson, Scott D.

Dry, Sarah M.

× Dry, Sarah M.

en Dry, Sarah M.

Singh, Arun S.

× Singh, Arun S.

en Singh, Arun S.

Russell, Tara A.

× Russell, Tara A.

en Russell, Tara A.

Elliott, Irmina

× Elliott, Irmina

en Elliott, Irmina

Singh, Shree Ram

× Singh, Shree Ram

en Singh, Shree Ram

Kanaya, Fuminori

× Kanaya, Fuminori

en Kanaya, Fuminori

Eilber, Fritz C.

× Eilber, Fritz C.

en Eilber, Fritz C.

Hoffman, Robert M.

× Hoffman, Robert M.

en Hoffman, Robert M.

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
主題
言語 en
主題Scheme Other
主題 Liposarcoma
言語 en
主題Scheme Other
主題 Patient-derived orthotopic xenograft
言語 en
主題Scheme Other
主題 PDOX
言語 en
主題Scheme Other
主題 PDGFRA amplification
言語 en
主題Scheme Other
主題 Trabectedin
言語 en
主題Scheme Other
主題 Precision medicine
内容記述
内容記述タイプ Other
内容記述 Background: Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against several patient-derived orthotopic xenograft (PDOX) mouse models. Here, we compared the efficacy of first-line therapy, doxorubicin (DOX), and TRAB in a platelet-derived growth factor receptor-α (PDGFRA)-amplified PLPS.\nMethods: We used a fresh sample of PLPS tumor derived from a 68-year-old male patient diagnosed with a recurrent PLPS. Subcutaneous implantation of tumor tissue was performed in a nude mouse. After three weeks of implantation, tumor tissues were isolated and cut into small pieces. To match the patient a PDGFRA-amplified PLPS PDOX was created in the biceps femoris of nude mice. Mice were randomized into three groups: Group 1 (G1), control (untreated); Group 2 (G2), DOX-treated; Group 3 (G3), TRAB-treated. Measurement was done twice a week for tumor width, length, and mouse body weight.\nResults: The PLPS PDOX showed resistance towards DOX. However, TRAB could arrest the PLPS (p < 0.05 compared to control; p < 0.05 compared to DOX) without any significant changes in body-weight.\nConclusions: The data presented here suggest that for the individual patient the PLPS PDOX model could specifically distinguish both effective and ineffective drugs. This is especially crucial for PLPS because effective first-line therapy is harder to establish if it is not individualized.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47548
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12885-018-4703-0
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12885-018-4703-0
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1471-2407
収録物名
言語 en
収録物名 BMC Cancer
書誌情報
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