Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-12-21 |
タイトル |
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タイトル |
Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model |
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言語 |
en |
作成者 |
Kiyuna, Tasuku
Tome, Yasunori
Murakami, Takashi
Kawaguchi, Kei
Igarashi, Kentaro
Miyake, Kentaro
Miyake, Masuyo
Li, Yunfeng
Nelson, Scott D.
Dry, Sarah M.
Singh, Arun S.
Russell, Tara A.
Elliott, Irmina
Singh, Shree Ram
Kanaya, Fuminori
Eilber, Fritz C.
Hoffman, Robert M.
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Liposarcoma |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Patient-derived orthotopic xenograft |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
PDOX |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
PDGFRA amplification |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Trabectedin |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Precision medicine |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Background: Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against several patient-derived orthotopic xenograft (PDOX) mouse models. Here, we compared the efficacy of first-line therapy, doxorubicin (DOX), and TRAB in a platelet-derived growth factor receptor-α (PDGFRA)-amplified PLPS.\nMethods: We used a fresh sample of PLPS tumor derived from a 68-year-old male patient diagnosed with a recurrent PLPS. Subcutaneous implantation of tumor tissue was performed in a nude mouse. After three weeks of implantation, tumor tissues were isolated and cut into small pieces. To match the patient a PDGFRA-amplified PLPS PDOX was created in the biceps femoris of nude mice. Mice were randomized into three groups: Group 1 (G1), control (untreated); Group 2 (G2), DOX-treated; Group 3 (G3), TRAB-treated. Measurement was done twice a week for tumor width, length, and mouse body weight.\nResults: The PLPS PDOX showed resistance towards DOX. However, TRAB could arrest the PLPS (p < 0.05 compared to control; p < 0.05 compared to DOX) without any significant changes in body-weight.\nConclusions: The data presented here suggest that for the individual patient the PLPS PDOX model could specifically distinguish both effective and ineffective drugs. This is especially crucial for PLPS because effective first-line therapy is harder to establish if it is not individualized. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
Springer Nature |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/47548 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12885-018-4703-0 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12885-018-4703-0 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1471-2407 |
収録物名 |
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言語 |
en |
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収録物名 |
BMC Cancer |
書誌情報 |
巻 18,
発行日 2018-08-20
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