ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "2deafc99-e638-4311-ba7c-69718b29be10"}, "_deposit": {"id": "2011319", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011319"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011319", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kiyuna, Tasuku", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Murakami, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tome, Yasunori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawaguchi, Kei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Igarashi, Kentaro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Zhang, Yong", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Zhao, Ming", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Li, Yunfeng", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Bouvet, Michael", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kanaya, Fuminori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Singh, Arun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Dry, Sarah", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Eilber, Fritz C.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hoffman, Robert M.", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution 3.0"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by/3.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by/3.0/"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Salmonella typhimurium A1-R"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "tumor-targeting"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "GFP"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "sarcoma"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "soft-tissue"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Follicular dendritic-cell sarcoma (FDCS) is a rare and recalcitrant disease. In the present study, a patient-derived orthotopic xenograft (PDOX) mouse model of FDCS was established in the biceps muscle of nude mice. The FDCS PDOX was resistant to both doxorubicin (DOX) and NVP-BEZ235, dactolisib (BEZ) an experimental agent which is a dual pan-phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor. However, in contrast to DOX and BEZ, the FDCS PDOX was sensitive to the tumor-targeting bacterial strain, Salmonella typhimurium A1-R (S. typhimurium A1-R). The combination of S. typhimurium A1-R and either DOX or BEZ did not increase the antitumor efficacy of S. typhimurium A1-R, indicating that DOX and BEZ were not active in this PDOX model. The efficacy of S. typhimurium A1-R in this recalcitrant FDCS gives strong impetus to move bacterial therapy to clinical trials for this disease. The findings of the present study are of particular importance since it demonstrates that S. typhimurium A1-R is effective in a PDOX model of FDCS established from a patient who failed DOX therapy.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Impact Journals"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/47567"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1949-2553"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Oncotarget"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "22", "bibliographicPageEnd": "33054", "bibliographicPageStart": "33046", "bibliographicVolumeNumber": "7"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.18632/oncotarget.8848"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.18632/oncotarget.8848"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "8848-134287-4-PB.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2011319/files/8848-134287-4-PB.pdf"}, "version_id": "f22d0501-ad50-438e-9700-5bcdf2816801"}]}, "item_title": "High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/47567", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-12-22"}, "publish_date": "2020-12-22", "publish_status": "0", "recid": "2011319", "relation": {}, "relation_version_is_last": true, "title": ["High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model"], "weko_shared_id": -1}
  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model

http://hdl.handle.net/20.500.12000/47567
http://hdl.handle.net/20.500.12000/47567
bd8f8eb3-18f2-42d2-b5b1-43ca41cce432
名前 / ファイル ライセンス アクション
8848-134287-4-PB.pdf 8848-134287-4-PB.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-22
タイトル
タイトル High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model
言語 en
作成者 Kiyuna, Tasuku

× Kiyuna, Tasuku

en Kiyuna, Tasuku

Murakami, Takashi

× Murakami, Takashi

en Murakami, Takashi

Tome, Yasunori

× Tome, Yasunori

en Tome, Yasunori

Kawaguchi, Kei

× Kawaguchi, Kei

en Kawaguchi, Kei

Igarashi, Kentaro

× Igarashi, Kentaro

en Igarashi, Kentaro

Zhang, Yong

× Zhang, Yong

en Zhang, Yong

Zhao, Ming

× Zhao, Ming

en Zhao, Ming

Li, Yunfeng

× Li, Yunfeng

en Li, Yunfeng

Bouvet, Michael

× Bouvet, Michael

en Bouvet, Michael

Kanaya, Fuminori

× Kanaya, Fuminori

en Kanaya, Fuminori

Singh, Arun

× Singh, Arun

en Singh, Arun

Dry, Sarah

× Dry, Sarah

en Dry, Sarah

Eilber, Fritz C.

× Eilber, Fritz C.

en Eilber, Fritz C.

Hoffman, Robert M.

× Hoffman, Robert M.

en Hoffman, Robert M.

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 3.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/3.0/
権利情報 https://creativecommons.org/licenses/by/3.0/
主題
言語 en
主題Scheme Other
主題 Salmonella typhimurium A1-R
言語 en
主題Scheme Other
主題 tumor-targeting
言語 en
主題Scheme Other
主題 GFP
言語 en
主題Scheme Other
主題 sarcoma
言語 en
主題Scheme Other
主題 soft-tissue
内容記述
内容記述タイプ Other
内容記述 Follicular dendritic-cell sarcoma (FDCS) is a rare and recalcitrant disease. In the present study, a patient-derived orthotopic xenograft (PDOX) mouse model of FDCS was established in the biceps muscle of nude mice. The FDCS PDOX was resistant to both doxorubicin (DOX) and NVP-BEZ235, dactolisib (BEZ) an experimental agent which is a dual pan-phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor. However, in contrast to DOX and BEZ, the FDCS PDOX was sensitive to the tumor-targeting bacterial strain, Salmonella typhimurium A1-R (S. typhimurium A1-R). The combination of S. typhimurium A1-R and either DOX or BEZ did not increase the antitumor efficacy of S. typhimurium A1-R, indicating that DOX and BEZ were not active in this PDOX model. The efficacy of S. typhimurium A1-R in this recalcitrant FDCS gives strong impetus to move bacterial therapy to clinical trials for this disease. The findings of the present study are of particular importance since it demonstrates that S. typhimurium A1-R is effective in a PDOX model of FDCS established from a patient who failed DOX therapy.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Impact Journals
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47567
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.18632/oncotarget.8848
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.18632/oncotarget.8848
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1949-2553
収録物名
言語 en
収録物名 Oncotarget
書誌情報
巻 7, 号 22, p. 33046-33054
戻る
0
views
See details
Views

Versions

Ver.1 2022-02-01 06:41:43.781794
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON

確認


Powered by WEKO3


Powered by WEKO3