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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 国際地域創造学部

The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women : The Kyushu Okinawa Maternal and Child Health Study

http://hdl.handle.net/20.500.12000/48295
http://hdl.handle.net/20.500.12000/48295
e5fb43b9-2aa1-499d-a774-f2116d2e9892
名前 / ファイル ライセンス アクション
243_159.pdf 243_159.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-04-20
タイトル
タイトル The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women : The Kyushu Okinawa Maternal and Child Health Study
言語 en
作成者 Tanaka, Keiko

× Tanaka, Keiko

en Tanaka, Keiko

Miyake, Yoshihiro

× Miyake, Yoshihiro

en Miyake, Yoshihiro

Hanioka, Takashi

× Hanioka, Takashi

en Hanioka, Takashi

Furukawa, Shinya

× Furukawa, Shinya

en Furukawa, Shinya

Miyatake, Nobuyuki

× Miyatake, Nobuyuki

en Miyatake, Nobuyuki

Arakawa, Masashi

× Arakawa, Masashi

en Arakawa, Masashi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © 2017 Tohoku University Medical Press
主題
言語 en
主題Scheme Other
主題 case-control study
言語 en
主題Scheme Other
主題 IL18
言語 en
主題Scheme Other
主題 Japan
言語 en
主題Scheme Other
主題 periodontal disease
言語 en
主題Scheme Other
主題 polymorphism
内容記述
内容記述タイプ Other
内容記述 Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in periodontitis and its polymorphisms might modulate the individual susceptibility to periodontitis. Only a limited number of studies on the association between IL18 single-nucleotide polymorphisms (SNPs) and the risk of periodontitis have been realized, however. The aim of this case-control study among young post-partum Japanese women (18 to 45 years) was to determine the impact of SNPs, rs1946518 (–607 C/A) and rs187238 (–137G/C), on periodontitis. The two SNPs may be located within a transcription factor-binding element, thereby influencing transcription from the IL18 promoter. Subjects were 131 cases who had at least one tooth with a probing pocket depth of ≥ 4.0 mm and 1,017 periodontally healthy controls. Probing pocket depth measurements were performed between 1 and 12 months post-partum. In this population, the A allele of rs1946518 and the C allele of rs187238 are more common. After adjustment for age, education, smoking, and use of an interdental brush, compared with subjects with the AA or AC genotype of SNP rs1946518, those with the CC genotype had a significantly reduced risk of periodontitis (adjusted odds ratio = 0.54, 95% confidence interval = 0.29-0.97). No significant association was observed between rs187238 and the risk of periodontitis. Our study did not reveal any evidence of interaction between the IL18 polymorphisms and smoking. Our findings indicate that the IL18 promoter SNP, rs1946518, is a potential risk factor of periodontitis among young Japanese women.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Tohoku University Medical Press
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/48295
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1620/tjem.243.159
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1620/tjem.243.159
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-3329
収録物識別子タイプ ISSN
収録物識別子 0040-8727
収録物名
言語 en
収録物名 The Tohoku Journal of Experimental Medicine
書誌情報
巻 243, 号 3, p. 159-164
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