| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2021-04-20 |
| タイトル |
|
|
タイトル |
The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women : The Kyushu Okinawa Maternal and Child Health Study |
|
言語 |
en |
| 作成者 |
Tanaka, Keiko
Miyake, Yoshihiro
Hanioka, Takashi
Furukawa, Shinya
Miyatake, Nobuyuki
Arakawa, Masashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
© 2017 Tohoku University Medical Press |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
case-control study |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL18 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Japan |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
periodontal disease |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
polymorphism |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in periodontitis and its polymorphisms might modulate the individual susceptibility to periodontitis. Only a limited number of studies on the association between IL18 single-nucleotide polymorphisms (SNPs) and the risk of periodontitis have been realized, however. The aim of this case-control study among young post-partum Japanese women (18 to 45 years) was to determine the impact of SNPs, rs1946518 (–607 C/A) and rs187238 (–137G/C), on periodontitis. The two SNPs may be located within a transcription factor-binding element, thereby influencing transcription from the IL18 promoter. Subjects were 131 cases who had at least one tooth with a probing pocket depth of ≥ 4.0 mm and 1,017 periodontally healthy controls. Probing pocket depth measurements were performed between 1 and 12 months post-partum. In this population, the A allele of rs1946518 and the C allele of rs187238 are more common. After adjustment for age, education, smoking, and use of an interdental brush, compared with subjects with the AA or AC genotype of SNP rs1946518, those with the CC genotype had a significantly reduced risk of periodontitis (adjusted odds ratio = 0.54, 95% confidence interval = 0.29-0.97). No significant association was observed between rs187238 and the risk of periodontitis. Our study did not reveal any evidence of interaction between the IL18 polymorphisms and smoking. Our findings indicate that the IL18 promoter SNP, rs1946518, is a potential risk factor of periodontitis among young Japanese women. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
Tohoku University Medical Press |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
|
|
識別子 |
http://hdl.handle.net/20.500.12000/48295 |
|
識別子タイプ |
HDL |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1620/tjem.243.159 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1620/tjem.243.159 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-3329 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0040-8727 |
| 収録物名 |
|
|
収録物名 |
The Tohoku Journal of Experimental Medicine |
|
言語 |
en |
| 書誌情報 |
巻 243,
号 3,
p. 159-164,
発行日 2017
|
243_159.pdf
