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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 農学部

高血圧自然発症ラットの血圧上昇に及ぼすリポソーム化クロレラエキスの影響

http://hdl.handle.net/20.500.12000/48411
http://hdl.handle.net/20.500.12000/48411
22de0a4c-a07c-42ae-a194-fb94d815a6fd
名前 / ファイル ライセンス アクション
56_573.pdf 56_573.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-04-30
タイトル
タイトル 高血圧自然発症ラットの血圧上昇に及ぼすリポソーム化クロレラエキスの影響
言語 ja
作成者 高橋, 誠

× 高橋, 誠

ja 高橋, 誠

島田, ほしの

× 島田, ほしの

ja 島田, ほしの

北本, 大

× 北本, 大

ja 北本, 大

高良, 健作

× 高良, 健作

ja 高良, 健作

和田, 浩二

× 和田, 浩二

ja 和田, 浩二

Takahashi, Makoto

× Takahashi, Makoto

en Takahashi, Makoto

Shimada, Hoshino

× Shimada, Hoshino

en Shimada, Hoshino

Kitamoto, Dai

× Kitamoto, Dai

en Kitamoto, Dai

Takara, Kensaku

× Takara, Kensaku

en Takara, Kensaku

Wada, Koji

× Wada, Koji

en Wada, Koji

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © 2009 日本食品科学工学会
主題
言語 ja
主題Scheme Other
主題 リボソーム
言語 ja
主題Scheme Other
主題 クロレラ
言語 ja
主題Scheme Other
主題 機能性食品
言語 ja
主題Scheme Other
主題 血圧上昇抑制作用
言語 ja
主題Scheme Other
主題 アンジオテンシンⅠ変換酵素
内容記述
内容記述タイプ Other
内容記述 We prepared liposome-encapsulated chlorella extract (LEC) using lecithin via combined mechanochemical method of homogenization and microfluidization. LEC was confirmed to comprise small unilamellar vesicles with a diameter of approximately 150nm by freeze fracture electron microscopy. The bioactivity of LEC was examined for the suppressive e ect of hypertension on blood pressure of spontaneously hypertensive rats (SHR). Continuous 10-week administration of LEC (3.6% (w/w) chlorella extract diet) showed a significant anti-hypertensive e ect compared to the control administration for 8 and 10 weeks. Moreover, oral LEC administration showed much higher anti-hypertensive e ect compared to non-capsulated extract administration. In addition, the active substance responsible for anti-hypertensive e ect in the extract presumed to comprise the peptides was confirmed to have a strong ACE inhibitory activity (IC_<50> :0.014mg/ mL). However, the extract showed a decrease in its ACE inhibitory activity following enzymatic digestion. Consequently, encapsulation for oral administration of LEC prevented digestion of the chlorella extract allowing for its high anti-hypertensive e ect on SHR.
内容記述タイプ Other
内容記述 新しいタイプの機能性食品の開発を目的として,食品用レシチンを用いて,クロレラエキスを内包するリポソーム(LEC)の調製を行った.得られたLECを含む飼料で高血圧自然発症ラット(SHR)を長期飼育し,その血圧上昇抑制作用について検討した.また併せて,クロレラエキス中の活性成分およびLECにおける血圧上昇抑制の作用機序を推察するため,ACE阻害活性の測定を行った.(1) 超高圧ホモジナイザーの処理条件を100MPa, 1パスとして調製したLECの膜構造は1枚膜であり,リポソームの平均粒子径は150±32nmであった.(2) 連続投与試験において,クロレラエキス投与群では対照群と比べて収縮期血圧の有意な差を認めなかったが,LEC投与群では有意な収縮期血圧上昇の抑制が認められた.(3) クロレラエキス中の血圧上昇抑制に関与する成分はACE阻害活性を有するペプチドであると考えられた.また,クロレラエキスは人工消化液処理による著しい活性低下を示した.以上の結果から,LECの摂取ではクロレラエキスのリポソーム化によって消化酵素による分解が抑制されたために,SHRに対する血圧上昇抑制効果を示したと考えられた.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 日本食品科学工学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/48411
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3136/nskkk.56.573
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3136/nskkk.56.573
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1881-6681
収録物識別子タイプ ISSN
収録物識別子 1341-027X
収録物名
言語 ja
収録物名 日本食品科学工学会誌
書誌情報
巻 56, 号 11, p. 573-578
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