{"_buckets": {"deposit": "b358b341-3792-475a-a473-0c2c6e9e344e"}, "_deposit": {"id": "2011548", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011548"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011548", "sets": ["1642838338003", "1642838407312"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "\u9ad8\u8840\u5727\u81ea\u7136\u767a\u75c7\u30e9\u30c3\u30c8\u306e\u8840\u5727\u4e0a\u6607\u306b\u53ca\u307c\u3059\u30ea\u30dd\u30bd\u30fc\u30e0\u5316\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u306e\u5f71\u97ff", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Effect of Liposome-Encapsulated Chlorella Extract on Hypertension in Spontaneously Hypertensive Rats", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9ad8\u6a4b, \u8aa0", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u5cf6\u7530, \u307b\u3057\u306e", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u5317\u672c, \u5927", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u826f, \u5065\u4f5c", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u548c\u7530, \u6d69\u4e8c", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Takahashi, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shimada, Hoshino", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kitamoto, Dai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takara, Kensaku", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wada, Koji", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u00a9 2009 \u65e5\u672c\u98df\u54c1\u79d1\u5b66\u5de5\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "liposome"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "chlorella"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "functional food"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "anti-hypertensive effect"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "angiotensin I-converting enzyme"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u30ea\u30dc\u30bd\u30fc\u30e0"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u30af\u30ed\u30ec\u30e9"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u6a5f\u80fd\u6027\u98df\u54c1"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u8840\u5727\u4e0a\u6607\u6291\u5236\u4f5c\u7528"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u2160\u5909\u63db\u9175\u7d20"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "We prepared liposome-encapsulated chlorella extract (LEC) using lecithin via combined mechanochemical method of homogenization and microfluidization. LEC was confirmed to comprise small unilamellar vesicles with a diameter of approximately 150nm by freeze fracture electron microscopy. The bioactivity of LEC was examined for the suppressive e ect of hypertension on blood pressure of spontaneously hypertensive rats (SHR). Continuous 10-week administration of LEC (3.6\uff05 (w/w) chlorella extract diet) showed a significant anti-hypertensive e ect compared to the control administration for 8 and 10 weeks. Moreover, oral LEC administration showed much higher anti-hypertensive e ect compared to non-capsulated extract administration. In addition, the active substance responsible for anti-hypertensive e ect in the extract presumed to comprise the peptides was confirmed to have a strong ACE inhibitory activity (IC_\u003c50\u003e :0.014mg/ mL). However, the extract showed a decrease in its ACE inhibitory activity following enzymatic digestion. Consequently, encapsulation for oral administration of LEC prevented digestion of the chlorella extract allowing for its high anti-hypertensive e ect on SHR.", "subitem_description_type": "Other"}, {"subitem_description": "\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306e\u6a5f\u80fd\u6027\u98df\u54c1\u306e\u958b\u767a\u3092\u76ee\u7684\u3068\u3057\u3066\uff0c\u98df\u54c1\u7528\u30ec\u30b7\u30c1\u30f3\u3092\u7528\u3044\u3066\uff0c\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u3092\u5185\u5305\u3059\u308b\u30ea\u30dd\u30bd\u30fc\u30e0\uff08LEC\uff09\u306e\u8abf\u88fd\u3092\u884c\u3063\u305f\uff0e\u5f97\u3089\u308c\u305fLEC\u3092\u542b\u3080\u98fc\u6599\u3067\u9ad8\u8840\u5727\u81ea\u7136\u767a\u75c7\u30e9\u30c3\u30c8\uff08SHR\uff09\u3092\u9577\u671f\u98fc\u80b2\u3057\uff0c\u305d\u306e\u8840\u5727\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\uff0e\u307e\u305f\u4f75\u305b\u3066\uff0c\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u4e2d\u306e\u6d3b\u6027\u6210\u5206\u304a\u3088\u3073LEC\u306b\u304a\u3051\u308b\u8840\u5727\u4e0a\u6607\u6291\u5236\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u63a8\u5bdf\u3059\u308b\u305f\u3081\uff0cACE\u963b\u5bb3\u6d3b\u6027\u306e\u6e2c\u5b9a\u3092\u884c\u3063\u305f\uff0e\uff081\uff09\u3000\u8d85\u9ad8\u5727\u30db\u30e2\u30b8\u30ca\u30a4\u30b6\u30fc\u306e\u51e6\u7406\u6761\u4ef6\u3092100MPa, 1\u30d1\u30b9\u3068\u3057\u3066\u8abf\u88fd\u3057\u305fLEC\u306e\u819c\u69cb\u9020\u306f1\u679a\u819c\u3067\u3042\u308a\uff0c\u30ea\u30dd\u30bd\u30fc\u30e0\u306e\u5e73\u5747\u7c92\u5b50\u5f84\u306f150\u00b132nm\u3067\u3042\u3063\u305f\uff0e\uff082\uff09\u3000\u9023\u7d9a\u6295\u4e0e\u8a66\u9a13\u306b\u304a\u3044\u3066\uff0c\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u6295\u4e0e\u7fa4\u3067\u306f\u5bfe\u7167\u7fa4\u3068\u6bd4\u3079\u3066\u53ce\u7e2e\u671f\u8840\u5727\u306e\u6709\u610f\u306a\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u304c\uff0cLEC\u6295\u4e0e\u7fa4\u3067\u306f\u6709\u610f\u306a\u53ce\u7e2e\u671f\u8840\u5727\u4e0a\u6607\u306e\u6291\u5236\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\uff083\uff09\u3000\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u4e2d\u306e\u8840\u5727\u4e0a\u6607\u6291\u5236\u306b\u95a2\u4e0e\u3059\u308b\u6210\u5206\u306fACE\u963b\u5bb3\u6d3b\u6027\u3092\u6709\u3059\u308b\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\uff0e\u307e\u305f\uff0c\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u306f\u4eba\u5de5\u6d88\u5316\u6db2\u51e6\u7406\u306b\u3088\u308b\u8457\u3057\u3044\u6d3b\u6027\u4f4e\u4e0b\u3092\u793a\u3057\u305f\uff0e\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\uff0cLEC\u306e\u6442\u53d6\u3067\u306f\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u306e\u30ea\u30dd\u30bd\u30fc\u30e0\u5316\u306b\u3088\u3063\u3066\u6d88\u5316\u9175\u7d20\u306b\u3088\u308b\u5206\u89e3\u304c\u6291\u5236\u3055\u308c\u305f\u305f\u3081\u306b\uff0cSHR\u306b\u5bfe\u3059\u308b\u8840\u5727\u4e0a\u6607\u6291\u5236\u52b9\u679c\u3092\u793a\u3057\u305f\u3068\u8003\u3048\u3089\u308c\u305f\uff0e", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u65e5\u672c\u98df\u54c1\u79d1\u5b66\u5de5\u5b66\u4f1a"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/48411"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1881-6681"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1341-027X"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u65e5\u672c\u98df\u54c1\u79d1\u5b66\u5de5\u5b66\u4f1a\u8a8c"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "11", "bibliographicPageEnd": "578", "bibliographicPageStart": "573", "bibliographicVolumeNumber": "56"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.3136/nskkk.56.573"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.3136/nskkk.56.573"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "56_573.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2011548/files/56_573.pdf"}, "version_id": "c6a47535-6c97-42de-8a0c-d8312591ed14"}]}, "item_title": "\u9ad8\u8840\u5727\u81ea\u7136\u767a\u75c7\u30e9\u30c3\u30c8\u306e\u8840\u5727\u4e0a\u6607\u306b\u53ca\u307c\u3059\u30ea\u30dd\u30bd\u30fc\u30e0\u5316\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u306e\u5f71\u97ff", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407312"], "permalink_uri": "http://hdl.handle.net/20.500.12000/48411", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-04-30"}, "publish_date": "2021-04-30", "publish_status": "0", "recid": "2011548", "relation": {}, "relation_version_is_last": true, "title": ["\u9ad8\u8840\u5727\u81ea\u7136\u767a\u75c7\u30e9\u30c3\u30c8\u306e\u8840\u5727\u4e0a\u6607\u306b\u53ca\u307c\u3059\u30ea\u30dd\u30bd\u30fc\u30e0\u5316\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u306e\u5f71\u97ff"], "weko_shared_id": -1}
高血圧自然発症ラットの血圧上昇に及ぼすリポソーム化クロレラエキスの影響
http://hdl.handle.net/20.500.12000/48411
http://hdl.handle.net/20.500.12000/48411