{"_buckets": {"deposit": "b358b341-3792-475a-a473-0c2c6e9e344e"}, "_deposit": {"id": "2011548", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011548"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011548", "sets": ["1642838338003", "1642838407312"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "\u9ad8\u8840\u5727\u81ea\u7136\u767a\u75c7\u30e9\u30c3\u30c8\u306e\u8840\u5727\u4e0a\u6607\u306b\u53ca\u307c\u3059\u30ea\u30dd\u30bd\u30fc\u30e0\u5316\u30af\u30ed\u30ec\u30e9\u30a8\u30ad\u30b9\u306e\u5f71\u97ff", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Effect of Liposome-Encapsulated Chlorella Extract on Hypertension in Spontaneously Hypertensive Rats", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9ad8\u6a4b, \u8aa0", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u5cf6\u7530, \u307b\u3057\u306e", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u5317\u672c, \u5927", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u826f, \u5065\u4f5c", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u548c\u7530, \u6d69\u4e8c", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Takahashi, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shimada, Hoshino", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kitamoto, Dai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takara, Kensaku", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wada, Koji", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u00a9 2009 \u65e5\u672c\u98df\u54c1\u79d1\u5b66\u5de5\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "liposome"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "chlorella"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "functional food"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "anti-hypertensive effect"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "angiotensin I-converting enzyme"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u30ea\u30dc\u30bd\u30fc\u30e0"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u30af\u30ed\u30ec\u30e9"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u6a5f\u80fd\u6027\u98df\u54c1"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u8840\u5727\u4e0a\u6607\u6291\u5236\u4f5c\u7528"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u2160\u5909\u63db\u9175\u7d20"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "We prepared liposome-encapsulated chlorella extract (LEC) using lecithin via combined mechanochemical method of homogenization and microfluidization. LEC was confirmed to comprise small unilamellar vesicles with a diameter of approximately 150nm by freeze fracture electron microscopy. The bioactivity of LEC was examined for the suppressive e ect of hypertension on blood pressure of spontaneously hypertensive rats (SHR). Continuous 10-week administration of LEC (3.6\uff05 (w/w) chlorella extract diet) showed a significant anti-hypertensive e ect compared to the control administration for 8 and 10 weeks. Moreover, oral LEC administration showed much higher anti-hypertensive e ect compared to non-capsulated extract administration. In addition, the active substance responsible for anti-hypertensive e ect in the extract presumed to comprise the peptides was confirmed to have a strong ACE inhibitory activity (IC_\u003c50\u003e :0.014mg/ mL). However, the extract showed a decrease in its ACE inhibitory activity following enzymatic digestion. Consequently, encapsulation for oral administration of LEC prevented digestion of the chlorella extract allowing for its high anti-hypertensive e ect on SHR.", "subitem_description_type": "Other"}, {"subitem_description": 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