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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 農学部

Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer’s Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies

http://hdl.handle.net/20.500.12000/44786
http://hdl.handle.net/20.500.12000/44786
1c1dddbf-3d8f-484e-ae74-2e505b5a4267
名前 / ファイル ライセンス アクション
vol23_n10_p1.pdf vol23_n10_p1.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2019-09-10
タイトル
タイトル Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer’s Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies
言語 ja
作成者 Shahinozzaman, Md

× Shahinozzaman, Md

en Shahinozzaman, Md

Taira, Nozomi

× Taira, Nozomi

en Taira, Nozomi

Ishii, Takahiro

× Ishii, Takahiro

en Ishii, Takahiro

Halim, Mohammad A

× Halim, Mohammad A

en Halim, Mohammad A

Hossain, Amzad Md

× Hossain, Amzad Md

en Hossain, Amzad Md

Tawata, Shinkichi

× Tawata, Shinkichi

en Tawata, Shinkichi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 ja
主題Scheme Other
主題 α-glucosidase
内容記述
内容記述タイプ Other
内容記述 Okinawa propolis (OP) and its major ingredients were reported to have anti-cancer effects and lifespan-extending effects on Caenorhabditis elegans through inactivation of the oncogenic kinase, p21-activated kinase 1 (PAK1). Herein, five prenylated flavonoids from OP, nymphaeol-A (NA), nymphaeol-B (NB), nymphaeol-C (NC), isonymphaeol-B (INB), and 3′-geranyl-naringenin (GN), were evaluated for their anti-inflammatory, anti-diabetic, and anti-Alzheimer’s effects using in vitro techniques. They showed significant anti-inflammatory effects through inhibition of albumin denaturation (half maximal inhibitory concentration (IC50) values of 0.26–1.02 µM), nitrite accumulation (IC50 values of 2.4–7.0 µM), and cyclooxygenase-2 (COX-2) activity (IC50 values of 11.74–24.03 µM). They also strongly suppressed in vitro α-glucosidase enzyme activity with IC50 values of 3.77–5.66 µM. However, only INB and NA inhibited acetylcholinesterase significantly compared to the standard drug donepezil, with IC_50 values of 7.23 and 7.77 µM, respectively. Molecular docking results indicated that OP compounds have good binding affinity to the α-glucosidase and acetylcholinesterase proteins, making non-bonded interactions with their active residues and surrounding allosteric residues. In addition, none of the compounds violated Lipinski’s rule of five and showed notable toxicity parameters. Density functional theory (DFT)-based global reactivity descriptors demonstrated their high reactive nature along with the kinetic stability. In conclusion, this combined study suggests that OP components might be beneficial in the treatment of inflammation, type 2 diabetes mellitus, and Alzheimer’s disease.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 MDPI
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/44786
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/molecules23102479
関連識別子
識別子タイプ DOI
関連識別子 10.3390/molecules23102479
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1420-3049
収録物名
言語 en
収録物名 Molecules
書誌情報
巻 23, 号 10, p. 1-18
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