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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease : functional role of exosomes.

http://hdl.handle.net/20.500.12000/45205
http://hdl.handle.net/20.500.12000/45205
8abbbbfa-c271-412a-a2a2-50e65d8e09c6
名前 / ファイル ライセンス アクション
Viral Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-01-16
タイトル
タイトル Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease : functional role of exosomes.
言語 en
作成者 Anderson, Monique R.

× Anderson, Monique R.

en Anderson, Monique R.

Pleet, Michelle L.

× Pleet, Michelle L.

en Pleet, Michelle L.

Enose-Akahata, Yoshimi

× Enose-Akahata, Yoshimi

en Enose-Akahata, Yoshimi

Erickson, James

× Erickson, James

en Erickson, James

Monaco, Maria Chiara

× Monaco, Maria Chiara

en Monaco, Maria Chiara

Akpamagbo, Yao

× Akpamagbo, Yao

en Akpamagbo, Yao

Velluchi, Ashley

× Velluchi, Ashley

en Velluchi, Ashley

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Azodi, Shila

× Azodi, Shila

en Azodi, Shila

Lepene, Ben

× Lepene, Ben

en Lepene, Ben

Jones, Jennifer

× Jones, Jennifer

en Jones, Jennifer

Kashanchi, Fatah

× Kashanchi, Fatah

en Kashanchi, Fatah

Jacobson, Steven

× Jacobson, Steven

en Jacobson, Steven

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
内容記述
内容記述タイプ Other
内容記述 HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The detection of HTLV-1 specific T cells in the cerebrospinal fluid (CSF) suggests this disease is immunopathologically mediated and that it may be driven by viral antigens. Exosomes are microvesicles originating from the endosomal compartment that are shed into the extracellular space by various cell types. It is now understood that several viruses take advantage of this mode of intercellular communication for packaging of viral components as well. We sought to understand if this is the case in HTLV-1 infection, and specifically if HTLV-1 proteins can be found in the CSF of HAM/TSP patients where we know free virus is absent, and furthermore, if exosomes containing HTLV-1 Tax have functional consequences.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 SpringerOpen
言語 en
出版者 Springer Berlin Heidelberg
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45205
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s40169-018-0204-7
関連識別子
識別子タイプ DOI
関連識別子 10.1186/s40169-018-0204-7
関連識別子
識別子タイプ PMID
関連識別子 30146667
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2001-1326
収録物名
言語 en
収録物名 Clinical and Translational Medicine
書誌情報
巻 7, 号 24, 発行日 2018-08-27
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