Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-01-16 |
タイトル |
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タイトル |
Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease : functional role of exosomes. |
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言語 |
en |
作成者 |
Anderson, Monique R.
Pleet, Michelle L.
Enose-Akahata, Yoshimi
Erickson, James
Monaco, Maria Chiara
Akpamagbo, Yao
Velluchi, Ashley
Tanaka, Yuetsu
Azodi, Shila
Lepene, Ben
Jones, Jennifer
Kashanchi, Fatah
Jacobson, Steven
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The detection of HTLV-1 specific T cells in the cerebrospinal fluid (CSF) suggests this disease is immunopathologically mediated and that it may be driven by viral antigens. Exosomes are microvesicles originating from the endosomal compartment that are shed into the extracellular space by various cell types. It is now understood that several viruses take advantage of this mode of intercellular communication for packaging of viral components as well. We sought to understand if this is the case in HTLV-1 infection, and specifically if HTLV-1 proteins can be found in the CSF of HAM/TSP patients where we know free virus is absent, and furthermore, if exosomes containing HTLV-1 Tax have functional consequences. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
SpringerOpen |
出版者 |
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言語 |
en |
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出版者 |
Springer Berlin Heidelberg |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/45205 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s40169-018-0204-7 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s40169-018-0204-7 |
関連情報 |
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識別子タイプ |
PMID |
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関連識別子 |
30146667 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2001-1326 |
収録物名 |
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言語 |
en |
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収録物名 |
Clinical and Translational Medicine |
書誌情報 |
巻 7,
号 24,
発行日 2018-08-27
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