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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Comparison of two screening tests for HIV-Associated Neurocognitive Disorder suspected Japanese patients with respect to cART usage

http://hdl.handle.net/20.500.12000/45641
http://hdl.handle.net/20.500.12000/45641
5fecf834-2523-441f-b157-51c75b1b0841
名前 / ファイル ライセンス アクション
journal.pone.0199106.pdf journal.pone.0199106.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-04-15
タイトル
タイトル Comparison of two screening tests for HIV-Associated Neurocognitive Disorder suspected Japanese patients with respect to cART usage
言語 en
作成者 Kami-Onaga, Kaoru

× Kami-Onaga, Kaoru

en Kami-Onaga, Kaoru

Tateyama, Masao

× Tateyama, Masao

en Tateyama, Masao

Kinjo, Takeshi

× Kinjo, Takeshi

en Kinjo, Takeshi

Parrott, Gretchen

× Parrott, Gretchen

en Parrott, Gretchen

Tominaga, Daisuke

× Tominaga, Daisuke

en Tominaga, Daisuke

Takahashi-Nakazato, Ai

× Takahashi-Nakazato, Ai

en Takahashi-Nakazato, Ai

Nakamura, Hideta

× Nakamura, Hideta

en Nakamura, Hideta

Tasato, Daisuke

× Tasato, Daisuke

en Tasato, Daisuke

Miyagi, Kyoko

× Miyagi, Kyoko

en Miyagi, Kyoko

Maeda, Saori

× Maeda, Saori

en Maeda, Saori

Arae, Hirotaka

× Arae, Hirotaka

en Arae, Hirotaka

Uehara, Hitoshi

× Uehara, Hitoshi

en Uehara, Hitoshi

Miyagi, Kazuya

× Miyagi, Kazuya

en Miyagi, Kazuya

Haranaga, Shusaku

× Haranaga, Shusaku

en Haranaga, Shusaku

Fujita, Jiro

× Fujita, Jiro

en Fujita, Jiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution License 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
内容記述
内容記述タイプ Other
内容記述 In this study, we demonstrated the pervasiveness of HIV-associated neurocognitive disorders (HAND) among a selection of Japanese patients as well as evaluated and comparedthe Mini Mental State Examination (MMSE) and the International HIV Dementia Scale(IHDS) for use as a screening tool among combination anti-retroviral therapy (cART)-naïveand cART experienced patients. The MMSE and the IHDS have both been used as HANDscreening tests around the world with variable success. It has been reported the increasedusage of cART the utility of these screening tests may have been diminished due to thedecreased severity of impairment and the altered pattern of neurocognitive impairments incART era HAND patients. It is therefore possible the MMSE and the IHDS may still be usefulamong cART-naïve patients even in the cART era. However, only one study has investigated and compared the screening results of the IHDS among cART-naïve and cART experienced patients. All HIV positive patients who visited, or were admitted, to the RyukyuUniversity Hospital between January 2009 and March 2014 were evaluated for inclusion.Selected patients (n = 49) had data without omission for all tests. The overall prevalence ofHAND in our cohort was 44%. The area under the curve (AUC), for all subjects using theMMSE and the IHDS, were 0.60 and 0.69, respectively. However, the AUC among cARTnaïve patients were 0.58 and 0.76 for the MMSE and the IHDS, respectively. Whereas,cART experienced patients had an AUC of 0.60 and 0.61, respectively. Overall, the MMSEdemonstrated a poor screening ability for HAND, regardless of cART usage (the cut-offvalue of 27 had a Youden’s J-Index of 0.1, in all groups). Alternatively, the IHDS was moderately useful for HAND screening among cART-naïve patients (the cut-off value of 11 had aYouden’s J-Index of 0.4), but performed poorly as a screening test among cART experienced patients (the cut-off value of 11 had a Youden’s J-Index of 0.1).
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45641
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0199106
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0199106
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1932-6203
収録物名
言語 en
収録物名 PLOS ONE
書誌情報
巻 13, 号 6
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