Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-04-15 |
タイトル |
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タイトル |
Comparison of two screening tests for HIV-Associated Neurocognitive Disorder suspected Japanese patients with respect to cART usage |
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言語 |
en |
作成者 |
Kami-Onaga, Kaoru
Tateyama, Masao
Kinjo, Takeshi
Parrott, Gretchen
Tominaga, Daisuke
Takahashi-Nakazato, Ai
Nakamura, Hideta
Tasato, Daisuke
Miyagi, Kyoko
Maeda, Saori
Arae, Hirotaka
Uehara, Hitoshi
Miyagi, Kazuya
Haranaga, Shusaku
Fujita, Jiro
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution License 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
In this study, we demonstrated the pervasiveness of HIV-associated neurocognitive disorders (HAND) among a selection of Japanese patients as well as evaluated and comparedthe Mini Mental State Examination (MMSE) and the International HIV Dementia Scale(IHDS) for use as a screening tool among combination anti-retroviral therapy (cART)-naïveand cART experienced patients. The MMSE and the IHDS have both been used as HANDscreening tests around the world with variable success. It has been reported the increasedusage of cART the utility of these screening tests may have been diminished due to thedecreased severity of impairment and the altered pattern of neurocognitive impairments incART era HAND patients. It is therefore possible the MMSE and the IHDS may still be usefulamong cART-naïve patients even in the cART era. However, only one study has investigated and compared the screening results of the IHDS among cART-naïve and cART experienced patients. All HIV positive patients who visited, or were admitted, to the RyukyuUniversity Hospital between January 2009 and March 2014 were evaluated for inclusion.Selected patients (n = 49) had data without omission for all tests. The overall prevalence ofHAND in our cohort was 44%. The area under the curve (AUC), for all subjects using theMMSE and the IHDS, were 0.60 and 0.69, respectively. However, the AUC among cARTnaïve patients were 0.58 and 0.76 for the MMSE and the IHDS, respectively. Whereas,cART experienced patients had an AUC of 0.60 and 0.61, respectively. Overall, the MMSEdemonstrated a poor screening ability for HAND, regardless of cART usage (the cut-offvalue of 27 had a Youden’s J-Index of 0.1, in all groups). Alternatively, the IHDS was moderately useful for HAND screening among cART-naïve patients (the cut-off value of 11 had aYouden’s J-Index of 0.4), but performed poorly as a screening test among cART experienced patients (the cut-off value of 11 had a Youden’s J-Index of 0.1). |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
Public Library of Science |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/45641 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0199106 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0199106 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1932-6203 |
収録物名 |
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言語 |
en |
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収録物名 |
PLOS ONE |
書誌情報 |
巻 13,
号 6,
発行日 2018-06-14
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