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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

http://hdl.handle.net/20.500.12000/45638
http://hdl.handle.net/20.500.12000/45638
e9327bb1-da65-4f95-9b56-cb04baa2e0f9
名前 / ファイル ライセンス アクション
journal.ppat.1005584.PDF journal.ppat.1005584.PDF
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-04-15
タイトル
タイトル HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains
言語 en
作成者 Wang, Chong

× Wang, Chong

en Wang, Chong

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Long, Wenying

× Long, Wenying

en Long, Wenying

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Peng, Chao

× Peng, Chao

en Peng, Chao

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Hu, Lin

× Hu, Lin

en Hu, Lin

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Zhang, Qiong

× Zhang, Qiong

en Zhang, Qiong

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Wu, Ailing

× Wu, Ailing

en Wu, Ailing

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Zhang, Xiaoqing

× Zhang, Xiaoqing

en Zhang, Xiaoqing

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Duan, Xiaotao

× Duan, Xiaotao

en Duan, Xiaotao

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Wong, Catherine C. L.

× Wong, Catherine C. L.

en Wong, Catherine C. L.

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Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

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Xia, Zongping

× Xia, Zongping

en Xia, Zongping

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution License 4.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
内容記述
内容記述タイプ Other
内容記述 The HTLV-1 oncoprotein Tax plays a key role in CD4+ T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in understanding HTLV-1-mediated transformation. Current studies have suggested multiple but controversial mechanisms regarding Tax-induced IKK activation mainly due to blending of primary Tax-induced IKK activation events and secondary IKK activation events induced by cytokines secreted by the primary Tax-induced IKK-NFκB activation events. We reconstituted Tax-stimulated IKK activation in a cell-free system to dissect the essential cellular components for primary IKK activation by Tax and studied the underlying biochemical mechanism. We found that Tax is a putative E3 ubiquitin ligase, which, together with UbcH2, UhcH5c, or UbcH7, catalyzes the assembly of free mixed-linkage polyubiquitin chains. These free mixed-linkage polyubiquitin chains are then responsible for direct IKK activation by binding to the NEMO subunit of IKK. Our studies revealed the biochemical function of Tax in the process of IKK activation, which utilizes the minimal cellular ubiquitination components for NF-κB activation.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45638
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.ppat.1005584
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.ppat.1005584
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1553-7374
収録物名
言語 en
収録物名 PLOS Pathogens
書誌情報
巻 12, 号 4, 発行日 2016-04-15
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