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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Production of a high level of specific IgG4 antibody associated with resistance to albendazole treatment in HLA-DRBI*0901-positive patients with strongyloidiasis

http://hdl.handle.net/20.500.12000/45869
http://hdl.handle.net/20.500.12000/45869
2d1c6495-ebcc-4cd3-8c5a-0e129af2c376
名前 / ファイル ライセンス アクション
10548308.pdf 10548308.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-05-22
タイトル
タイトル Production of a high level of specific IgG4 antibody associated with resistance to albendazole treatment in HLA-DRBI*0901-positive patients with strongyloidiasis
言語 en
作成者 Satoh, Masao

× Satoh, Masao

en Satoh, Masao

Toma, Hiromu

× Toma, Hiromu

en Toma, Hiromu

Sato, Yoshiya

× Sato, Yoshiya

en Sato, Yoshiya

Kikuchi, Mihoko

× Kikuchi, Mihoko

en Kikuchi, Mihoko

Takara, Masahiro

× Takara, Masahiro

en Takara, Masahiro

Shiroma, Yoshiyuki

× Shiroma, Yoshiyuki

en Shiroma, Yoshiyuki

Kiyuna, Susumu

× Kiyuna, Susumu

en Kiyuna, Susumu

Hirayama, Kenji

× Hirayama, Kenji

en Hirayama, Kenji

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 The American Society of Tropical Medicine and Hygiene
内容記述
内容記述タイプ Other
内容記述 Strongyloidiasis, a human intestinal infection with Strongyloides stercoralis, is difficult to treat with drugs. The factors influencing this phenomenon remain unclear. To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured, Serum levels of specific IgA, IgE, IgG, IgG1, and IgC4 antibodies were estimated using S. stercoralis antigen. Significantly higher titers of IgG4 antibody were observed in the non-cured group than in the cured group (P = 0.016). A total of 88 patients were typed for HLA-DRB1 alleles and analyzed for serum levels of antibody. The S. stercoralis-specific IgG4 antibody titers were significantly higher in the HLA-DRB1*0901-positive group than in the negative group (corrected P = 0.044). These results suggest that HLA-DRB1*0901 is a possible genetic marker for resistance to treatment of S. stercoralis that is associated with elevation of S. stercoralis-specific IgG4 antibody titer.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 The American Society of Tropical Medicine and Hygiene
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45869
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.4269/ajtmh.1999.61.668
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.4269/ajtmh.1999.61.668
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0002-9637
収録物識別子タイプ ISSN
収録物識別子 1476-1645
収録物名
言語 en
収録物名 The American Journal of Tropical Medicine and Hygiene
書誌情報
巻 61, 号 4, p. 668-671, 発行日 1999-10
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