Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-05-22 |
タイトル |
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タイトル |
Production of a high level of specific IgG4 antibody associated with resistance to albendazole treatment in HLA-DRBI*0901-positive patients with strongyloidiasis |
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言語 |
en |
作成者 |
Satoh, Masao
Toma, Hiromu
Sato, Yoshiya
Kikuchi, Mihoko
Takara, Masahiro
Shiroma, Yoshiyuki
Kiyuna, Susumu
Hirayama, Kenji
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
The American Society of Tropical Medicine and Hygiene |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Strongyloidiasis, a human intestinal infection with Strongyloides stercoralis, is difficult to treat with drugs. The factors influencing this phenomenon remain unclear. To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured, Serum levels of specific IgA, IgE, IgG, IgG1, and IgC4 antibodies were estimated using S. stercoralis antigen. Significantly higher titers of IgG4 antibody were observed in the non-cured group than in the cured group (P = 0.016). A total of 88 patients were typed for HLA-DRB1 alleles and analyzed for serum levels of antibody. The S. stercoralis-specific IgG4 antibody titers were significantly higher in the HLA-DRB1*0901-positive group than in the negative group (corrected P = 0.044). These results suggest that HLA-DRB1*0901 is a possible genetic marker for resistance to treatment of S. stercoralis that is associated with elevation of S. stercoralis-specific IgG4 antibody titer. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
The American Society of Tropical Medicine and Hygiene |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/45869 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.4269/ajtmh.1999.61.668 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.4269/ajtmh.1999.61.668 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0002-9637 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1476-1645 |
収録物名 |
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言語 |
en |
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収録物名 |
The American Journal of Tropical Medicine and Hygiene |
書誌情報 |
巻 61,
号 4,
p. 668-671,
発行日 1999-10
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