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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells

http://hdl.handle.net/20.500.12000/45871
http://hdl.handle.net/20.500.12000/45871
7e2c692b-cc6b-412e-bd07-1b464420af7b
名前 / ファイル ライセンス アクション
cas.13163.pdf cas.13163.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-05-22
タイトル
タイトル Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells
言語 en
作成者 Nasu, Kentaro

× Nasu, Kentaro

en Nasu, Kentaro

Yamaguchi, Kazunori

× Yamaguchi, Kazunori

en Yamaguchi, Kazunori

Takanashi, Tomoka

× Takanashi, Tomoka

en Takanashi, Tomoka

Tamai, Keiichi

× Tamai, Keiichi

en Tamai, Keiichi

Sato, Ikuro

× Sato, Ikuro

en Sato, Ikuro

Ine, Shoji

× Ine, Shoji

en Ine, Shoji

Sasaki, Osamu

× Sasaki, Osamu

en Sasaki, Osamu

Satoh, Kennichi

× Satoh, Kennichi

en Satoh, Kennichi

Tanaka, Nobuyuki

× Tanaka, Nobuyuki

en Tanaka, Nobuyuki

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Fukushima, Takuya

× Fukushima, Takuya

en Fukushima, Takuya

Harigae, Hideo

× Harigae, Hideo

en Harigae, Hideo

Sugamura, Kazuo

× Sugamura, Kazuo

en Sugamura, Kazuo

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Lisens Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 Adult T-cell leukemia/lymphoma
言語 en
主題Scheme Other
主題 carbonic anhydrase IX
言語 en
主題Scheme Other
主題 human T-cell leukemia virus type 1
言語 en
主題Scheme Other
主題 tumorigenicity
言語 en
主題Scheme Other
主題 xenotransplantation
内容記述
内容記述タイプ Other
内容記述 Carbonic anhydrase IX (CA9) is a membrane-associated carbonic anhydrase that regulates cellular pH, is upregulated in various solid tumors, and is considered to be a therapeutic target. Here, we describe the essential role of CA9 in the tumorigenicity of cells derived from human adult T-cell leukemia/lymphoma (ATL). We previously established the highly tumorigenic ST1-N6 subline from the ATL-derived ST1 cell line by serial xenotransplantation in NOG mice. In the present study, we first show that CA9 expression is strongly enhanced in ST1-N6 cells. We then sorted ST1 cells by high or low CA9 expression and established ST1-CA9(high) and ST1-CA9(low) sublines. ST1-CA9(high) cells, like ST1-N6 cells, were more strongly tumorigenic than ST1-CA9(low) or parental ST1 cells when injected into NOG mice. Knockdown of CA9 with shRNAs suppressed the ability of ST1-CA9(high) cells to initiate tumors, and the tumorigenicity of ST1 cells was significantly enhanced by introducing wild-type CA9 or a CA9 mutant with deletion of an intracytoplasmic domain. However, a CA9 with point mutations in the catalytic site did not increase the tumorigenicity of ST1 cells. Furthermore, we detected a small population of CA9(+)CD25(+) cells in lymph nodes of ATL patients. These findings suggest that CA9, and particularly its carbonic anhydrase activity, promotes the tumorigenicity of ATL-derived cells and may be involved in malignant development of lymphoma-type ATL.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45871
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.13163
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.13163
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-7006
収録物名
言語 en
収録物名 Cancer science
書誌情報
巻 108, 号 3, p. 435-443, 発行日 2017-03
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