| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2020-05-27 |
| タイトル |
|
|
タイトル |
A Unique Subset of γδ T Cells Expands and Produces IL-10 in Patients with Naturally Acquired Immunity against Falciparum Malaria |
|
言語 |
ja |
| 作成者 |
Taniguchi, Tomoyo
Mannoor, Kaiissar Md
Nonaka, Daisuke
Toma, Hiromu
Li, Changchun
Narita, Miwako
Vanisaveth, Viengxay
Kano, Shigeyuki
Takahashi, Masuhiro
Watanabe, Hisami
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Creative Commons Attribution 4.0 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| 主題 |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
γδ T cells |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
naturally acquired immunity |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Plasmodium falciparum |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
falciparum malaria |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-10 |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Although expansions in gamma delta T cell populations are known to occur in the peripheral blood of patients infected with Plasmodium falciparum, the role of these cells in people with naturally acquired immunity against P. falciparum who live in malaria-endemic areas is poorly understood. We used a cross-sectional survey to investigate the role of peripheral blood gamma delta T cells in people living in Lao People's Democratic Republic, a malaria-endemic area. We found that the proportion of non-V gamma 9 gamma delta T cells was higher in non-hospitalized uncomplicated falciparum malaria patients (UMPs) from this region. Notably, we found that the non-V gamma 9 gamma delta T cells in the peripheral blood of UMPs and negative controls from this region had the potential to expand and produce IL-10 and interferon-gamma when cultured in the presence of IL-2 and/or crude P. falciparum antigens for 10 days. Furthermore, these cells were associated with plasma interleukin 10 (IL-10), which was elevated in UMPs. This is the first report demonstrating that, in UMPs living in a malaria-endemic area, a gamma delta T cell subset, the non-V gamma 9 gamma delta T cells, expands and produces IL-10. These results contribute to understanding of the mechanisms of naturally acquired immunity against P. falciparum. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
Frontiers Media |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
|
|
識別子 |
http://hdl.handle.net/20.500.12000/45905 |
|
識別子タイプ |
HDL |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fmicb.2017.01288 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fmicb.2017.01288 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1664-302X |
| 収録物名 |
|
|
収録物名 |
Frontiers in Microbiology |
|
言語 |
en |
| 書誌情報 |
巻 8,
発行日 2017-07-19
|
fmicb-08-01288.pdf
