Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-06-02 |
タイトル |
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タイトル |
Determination of Urinary Caffeine Metabolites as Biomarkers for Drug Metabolic Enzyme Activities |
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言語 |
en |
作成者 |
Kim, Hyeong Jun
Choi, Min Sun
Rehman, Shaheed Ur
Ji, Young Seok
Yu, Jun Sang
Nakamura, Katsunori
Yoo, Hye Hyun
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
caffeine |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
metabolites |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
phenotyping |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
CYP450 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
NAT |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
xanthine oxidase |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Caffeine is commonly taken via the daily dietary consumption of caffeine-containing foods. The absorbed caffeine is metabolized to yield various metabolites by drug-metabolizing enzymes, and measuring the levels of each caffeine metabolite can provide useful information for evaluating the phenotypes of those enzymes. In this study, the urinary concentrations of caffeine and its 13 metabolites were determined, and the phenotypes of drug metabolic enzymes were investigated based on the caffeine metabolite ratios. Human urine samples were pretreated using solid phase extraction, and caffeine and its metabolites were analyzed using liquid chromatography-tandem mass spectrometry. Based on the urinary caffeine metabolite concentrations, the caffeine metabolite ratios were calculated for six human subjects at specified time points after caffeine intake. Variations in urinary metabolite levels among individuals and time points were reported. In addition, the resultant enzyme activities showed different patterns, depending on the metabolite ratio equations applied. However, some data presented a constant metabolite ratio range, irrespective of time points, even at pre-dose. This suggests the possibility of urinary caffeine metabolite analysis for routine clinical examination. These findings show that urinary caffeine and the metabolite analysis would be useful in evaluating metabolic phenotypes for personalized medicine. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
MDPI |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/45975 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/nu11081947 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/nu11081947 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2072-6643 |
収録物名 |
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言語 |
en |
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収録物名 |
Nutrients |
書誌情報 |
巻 11,
号 8,
発行日 2019-08
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