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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP

http://hdl.handle.net/20.500.12000/46016
http://hdl.handle.net/20.500.12000/46016
588df0ef-7760-4f8b-8dbd-e33f3cd30d8c
名前 / ファイル ライセンス アクション
s12977-018-0454-x.pdf s12977-018-0454-x.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-06-03
タイトル
タイトル Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP
言語 en
作成者 Naito, Tadasuke

× Naito, Tadasuke

en Naito, Tadasuke

Yasunaga, Jun-ichirou

× Yasunaga, Jun-ichirou

en Yasunaga, Jun-ichirou

Mitobe, Yuichi

× Mitobe, Yuichi

en Mitobe, Yuichi

Shirai, Kazumasa

× Shirai, Kazumasa

en Shirai, Kazumasa

Sejima, Hiroe

× Sejima, Hiroe

en Sejima, Hiroe

Ushirogawa, Hiroshi

× Ushirogawa, Hiroshi

en Ushirogawa, Hiroshi

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Nakamura, Tatsufumi

× Nakamura, Tatsufumi

en Nakamura, Tatsufumi

Hanada, Kousuke

× Hanada, Kousuke

en Hanada, Kousuke

Fujii, Masahiro

× Fujii, Masahiro

en Fujii, Masahiro

Matsuoka, Masao

× Matsuoka, Masao

en Matsuoka, Masao

Saito, Mineki

× Saito, Mineki

en Saito, Mineki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
主題
言語 en
主題Scheme Other
主題 HTLV-1
言語 en
主題Scheme Other
主題 Virus subgroup
言語 en
主題Scheme Other
主題 HAM/TSP
言語 en
主題Scheme Other
主題 Tax
言語 en
主題Scheme Other
主題 HBZ
言語 en
主題Scheme Other
主題 Microarray
内容記述
内容記述タイプ Other
内容記述 Background: Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. To investigate the role of HTLV-1 subgroups in viral pathogenesis, we studied the functional diference in the subgroupspecifc viral transcriptional regulators Tax and HBZ using microarray analysis, reporter gene assays, and evaluation of viral-host protein–protein interaction. Results: (1) Transcriptional changes in Jurkat Tet-On human T-cells that express each subgroup of Tax or HBZ protein under the control of an inducible promoter revealed diferent target gene profles; (2) the number of diferentially regulated genes induced by HBZ was 2–3 times higher than that induced by Tax; (3) Tax and HBZ induced the expres‑ sion of diferent classes of non-coding RNAs (ncRNAs); (4) the chemokine CXCL10, which has been proposed as a prognostic biomarker for HAM/TSP, was more efciently induced by subgroup-A Tax (Tax-A) than subgroup-B Tax (Tax-B), in vitro as well as in unmanipulated (ex vivo) PBMCs obtained from HAM/TSP patients; (5) reporter gene assays indicated that although transient Tax expression in an HTLV-1-negative human T-cell line activated the CXCL10 gene promoter through the NF-κB pathway, there was no diference in the ability of each subgroup of Tax to activate the CXCL10 promoter; however, (6) chromatin immunoprecipitation assays showed that the ternary complex containing Tax-A is more efciently recruited onto the promoter region of CXCL10, which contains two NF-κB binding sites, than that containing Tax-B. Conclusions: Our results indicate that diferent HTLV-1 subgroups are characterized by diferent patterns of host gene expression. Diferential expression of pathogenesis-related genes by subgroup-specifc Tax or HBZ may be asso‑ ciated with the onset of HAM/TSP.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 BioMed Central
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46016
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12977-018-0454-x
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12977-018-0454-x
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1742-4690
収録物名
言語 en
収録物名 Retrovirology
書誌情報
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