Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-06-08 |
タイトル |
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タイトル |
Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status |
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言語 |
en |
作成者 |
Shiohama, Yasuo
Naito, Tadasuke
Matsuzaki, Toshio
Tanaka, Reiko
Tomoyose, Takeaki
Takashima, Hiroshi
Fukushima, Takuya
Tanaka, Yuetsu
Saito, Mineki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
HTLV-1 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
NY-ESO-1 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
ATL |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
HAM/TSP |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Monoclonal antibody |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
ELISA |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Background:Detection of specific immune responses against cancer/testis antigen NY-ESO-1 was recently reported in patients with adult T-cell leukemia/lymphoma (ATL) and human T-cell leukemia virus type 1 (HTLV-1)-infected asymptomatic carriers (ACs). However, the relationship of the responses with the HTLV-1 proviral load (PVL) and the levels of viral gene expression remain unclear. Findings:We measured plasma levels of autoantibodies to NY-ESO-1 immunogenic tumor antigen in HTLV-1-infected individuals with different clinical status, and in healthy controls. Data were compared to tax and HBZ mRNA levels, and PVL. Plasma anti-NY-ESO-1 antibody was detectable in 13.7% (7/51) of ACs, 29.2% (38/130) of patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), and 18.9% (10/53) of patients with ATL. Anti-NY-ESO-1 plasma levels were significantly higher in patients with HAM/TSP than in patients with ATL or ACs. Anti-NY-ESO-1 levels were not associated with PVL or the expression levels of tax and HBZ mRNA among HTLV-1-infected individuals, regardless of clinical status. Conclusions:The present results indicate the strong humoral immune response against NY-ESO-1 in natural HTLV-1 infection, irrespective of the clinical status. The higher immunoreactivity against NY-ESO-1 is not simply associated with the levels of both HTLV-1 gene expression and the number of infected cells in vivo. Rather, it might reflect chronic and generalized immune activation in infected individuals. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
BioMed Central |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/46075 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12985-017-0802-9 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12985-017-0802-9 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1743-422X |
収録物名 |
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言語 |
en |
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収録物名 |
Virology Journal |
書誌情報 |
巻 14,
発行日 2017-07-17
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