| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2020-06-08 |
| タイトル |
|
|
タイトル |
A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I |
|
言語 |
en |
| 作成者 |
Fujii, Hideki
Shimizu, Mamoru
Miyagi, Takuya
Kunihiro, Marie
Tanaka, Reiko
Takahashi, Yoshiaki
Tanaka, Yuetsu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Creative Commons Attribution 4.0 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HTLV-I |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NOG mice |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neutralizing monoclonal antibody |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
envelope gp46 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
passive immunity |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Although the number of human T-cell leukemia virus type-I (HTLV-I)-infected individuals in the world has been estimated at over 10 million, no prophylaxis vaccines against HTLV-I infection are available. In this study, we took a new approach for establishing the basis of protective vaccines against HTLV-I. We show here the potential of a passively administered HTLV-I neutralizing monoclonal antibody of rat origin (LAT-27) that recognizes epitopes consisting of the HTLV-I gp46 amino acids 191–196. LAT-27 completely blocked HTLV-I infection in vitro at a minimum concentration of 5 μg/mL. Neonatal rats born to mother rats pre-infused with LAT-27 were shown to have acquired a large quantity of LAT-27, and these newborns showed complete resistance against intraperitoneal infection with HTLV-I. On the other hand, when humanized immunodeficient mice were pre-infused intravenously with humanized LAT-27 (hu-LAT-27), all the mice completely resisted HTLV-I infection. These results indicate that hu-LAT-27 may have a potential for passive immunization against both horizontal and mother-to-child vertical infection with HTLV-I. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
|
|
識別子 |
http://hdl.handle.net/20.500.12000/46074 |
|
識別子タイプ |
HDL |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/v8020041 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/v8020041 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1999-4915 |
| 収録物名 |
|
|
収録物名 |
Viruses |
|
言語 |
en |
| 書誌情報 |
巻 8,
号 2,
発行日 2016-02-03
|
viruses-08-00041.pdf
