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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14 : a case report

http://hdl.handle.net/20.500.12000/46329
http://hdl.handle.net/20.500.12000/46329
edc0b3d9-c5ff-490c-b83b-ee08e4e301ba
名前 / ファイル ライセンス アクション
ijcep0007-8972.pdf ijcep0007-8972.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-06-29
タイトル
タイトル Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14 : a case report
言語 en
作成者 Arakaki, Kazunari

× Arakaki, Kazunari

en Arakaki, Kazunari

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Chinen, Katsuya

× Chinen, Katsuya

en Chinen, Katsuya

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Kamiya, Masuzo

× Kamiya, Masuzo

en Kamiya, Masuzo

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Tanabe, Yasuka

× Tanabe, Yasuka

en Tanabe, Yasuka

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Tawata, Natsumi

× Tawata, Natsumi

en Tawata, Natsumi

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Ikehara, Fukino

× Ikehara, Fukino

en Ikehara, Fukino

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Uehara, Karina

× Uehara, Karina

en Uehara, Karina

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Shimabukuro, Hiroichi

× Shimabukuro, Hiroichi

en Shimabukuro, Hiroichi

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Kinjo, Takao

× Kinjo, Takao

en Kinjo, Takao

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial 4.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc/4.0/
権利情報 https://creativecommons.org/licenses/by-nc/4.0/
主題
言語 en
主題Scheme Other
主題 Cellular angiofibroma
主題
言語 en
主題Scheme Other
主題 monoallelic deletion
主題
言語 en
主題Scheme Other
主題 RB1
主題
言語 en
主題Scheme Other
主題 FOXO1
主題
言語 en
主題Scheme Other
主題 ROS
主題
言語 en
主題Scheme Other
主題 p38 MAPK
内容記述
内容記述タイプ Other
内容記述 Cellular angiofibroma (CAF) is a rare soft tissue tumor characterized by random arrangement of spindle tumor cells in the stroma with short collagen bundles and thick- and hyalinized small vessels. CAFs share histological characteristics with spindle cell lipomas and mammary type myofibroblastomas. Because these tumors harbor monoallelic 13q14, common genetic and molecular mechanism for tumorigenesis is presumed. In this study, we reported a case of CAF in a 69-year-old man with monoallelic 13q14. Immunohistochemical analysis revealed that FOXO1, which is located in chromosome 13q14, was not expressed in the tumor. We also detected oxidative stress markers and found p38 MAPK activation, which is often induced by cellular stressors such as reactive oxygen species (ROS). Because FOXO1 induces the expression of genes encoding enzymes that generate antioxidants, oxidative stress induced by loss of FOXO1 expression may be common among CAFs, spindle cell lipomas, and mammary type myofibroblastomas.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 e-Century Publishing Corporation
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46329
識別子タイプ HDL
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1936-2625
収録物名
言語 en
収録物名 International Journal of Clinical and Experimental Pathology
書誌情報
巻 7, 号 12, p. 8972-8979, 発行日 2014-12-01
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