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Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord
http://hdl.handle.net/20.500.12000/46545
http://hdl.handle.net/20.500.12000/4654585bd4e6e-8369-448e-b249-a4f05a11a16d
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-07-31 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Kosaka, Yoshinori
× Kosaka, Yoshinori
× Kin, Hidemichi
× Tatetsu, Masaharu
× Uema, Itsuki
× Takayama, Chitoshi
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| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||
| 権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | cervical cord | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | GABAergic synapse | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | glutamic acid decarboxylase (GAD) | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | potassium chloride co-transporter 2 (KCC2) | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | vesicular GABA transporter (VGAT) | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | In the adult brain, gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervical spinal cord. Glutamic acid decarboxylase and GABA were markers for GABA neurons. Vesicular GABA transporter was a marker for GABAergic and glycinergic terminals. Potassium chloride cotransporter 2 was a marker for GABAergic inhibition. We found five points: (1) In the ventral part, GABA neurons were divided into three groups. The first differentiated group sent commissural axons after embryonic day 11 (Ell), but disappeared or changed their transmitter by E15. The second and third differentiated groups were localized in the ventral horn after E12, and sent axons to the ipsilateral marginal zone. There was a distal-to-proximal gradient in varicosity formation in GABAergic axons and a superficial-to-deep gradient in GABAergic synapse formation in the ventral horn; (2) In the dorsal horn, GABA neurons were localized after E13, and synapses were diffusely formed after E15; (3) GABA may be excitatory for several days before synapses formation; (4) There was a ventral-to-dorsal gradient in the development of GABA signaling. The GABAergic inhibitory network may develop in the ventral horn between E15 and E17, and GABA may transiently play crucial roles in inhibitory regulation of the motor system in the mouse fetus; (5) GABA signaling continued to develop after birth, and GABAergic system diminished in the ventral horn. | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 論文 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 識別子 | ||||||||||||||||
| 識別子 | http://hdl.handle.net/20.500.12000/46545 | |||||||||||||||
| 識別子タイプ | HDL | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.brainres.2012.10.003 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.brainres.2012.10.003 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0006-8993 | |||||||||||||||
| 収録物名 | ||||||||||||||||
| 収録物名 | Brain Research | |||||||||||||||
| 言語 | en | |||||||||||||||
| 書誌情報 |
巻 1486, 号 27, p. 39-52, 発行日 2012-11-27 |
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