ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "1001ac2d-edde-40f1-9e3e-d6822a5e8fcd"}, "_deposit": {"id": "2012562", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2012562"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02012562", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kosaka, Yoshinori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kin, Hidemichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tatetsu, Masaharu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uema, Itsuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takayama, Chitoshi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "cervical cord"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "GABAergic synapse"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "glutamic acid decarboxylase (GAD)"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "potassium chloride co-transporter 2 (KCC2)"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "vesicular GABA transporter (VGAT)"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "In the adult brain, gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervical spinal cord. Glutamic acid decarboxylase and GABA were markers for GABA neurons. Vesicular GABA transporter was a marker for GABAergic and glycinergic terminals. Potassium chloride cotransporter 2 was a marker for GABAergic inhibition. We found five points: (1) In the ventral part, GABA neurons were divided into three groups. The first differentiated group sent commissural axons after embryonic day 11 (Ell), but disappeared or changed their transmitter by E15. The second and third differentiated groups were localized in the ventral horn after E12, and sent axons to the ipsilateral marginal zone. There was a distal-to-proximal gradient in varicosity formation in GABAergic axons and a superficial-to-deep gradient in GABAergic synapse formation in the ventral horn; (2) In the dorsal horn, GABA neurons were localized after E13, and synapses were diffusely formed after E15; (3) GABA may be excitatory for several days before synapses formation; (4) There was a ventral-to-dorsal gradient in the development of GABA signaling. The GABAergic inhibitory network may develop in the ventral horn between E15 and E17, and GABA may transiently play crucial roles in inhibitory regulation of the motor system in the mouse fetus; (5) GABA signaling continued to develop after birth, and GABAergic system diminished in the ventral horn.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Elsevier"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/46545"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0006-8993"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Brain Research"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "27", "bibliographicPageEnd": "52", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "1486"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "AM", "subitem_1600292170262": "http://purl.org/coar/version/c_ab4af688f83e57aa"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1016/j.brainres.2012.10.003"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1016/j.brainres.2012.10.003"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "Figure 9.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 9.tif"}, "version_id": "e1f5cff7-16fe-47d9-9988-14907dbf6652"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 1, "filename": "Figure 8.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 8.tif"}, "version_id": "9ec3a49d-af5f-49a9-9442-d228d4b606b3"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 2, "filename": "Figure 7.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 7.tif"}, "version_id": "b66afb56-64e6-424f-af6c-953ad9c8c2c7"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 3, "filename": "Figure 6.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 6.tif"}, "version_id": "a86abb2d-bda7-4d55-8aee-1a57293634eb"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 4, "filename": "Figure 5.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 5.tif"}, "version_id": "06169e37-42ef-404d-adc4-7641835b5476"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 5, "filename": "Figure 4.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 4.tif"}, "version_id": "d1a4e91f-f8e1-47ec-98f3-c84ef766c458"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 6, "filename": "Figure 3.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 3.tif"}, "version_id": "ac55410c-e84f-4ce5-87bc-cdb7d7090ec4"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 7, "filename": "Figure 2.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 2.tif"}, "version_id": "bb6fef19-85c6-42e9-9638-991bf0f87045"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 8, "filename": "Figure 1.tif", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/Figure 1.tif"}, "version_id": "29fdc1d2-02e4-4fd8-b2ef-8b325243162b"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 9, "filename": "1486.27.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012562/files/1486.27.pdf"}, "version_id": "56e48fba-5b59-4cd1-a07c-e00a46d1460b"}]}, "item_title": "Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/46545", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-07-31"}, "publish_date": "2020-07-31", "publish_status": "0", "recid": "2012562", "relation": {}, "relation_version_is_last": true, "title": ["Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord"], "weko_shared_id": -1}
  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord

http://hdl.handle.net/20.500.12000/46545
http://hdl.handle.net/20.500.12000/46545
85bd4e6e-8369-448e-b249-a4f05a11a16d
名前 / ファイル ライセンス アクション
Figure Figure 9.tif
Figure Figure 8.tif
Figure Figure 7.tif
Figure Figure 6.tif
Figure Figure 5.tif
Figure Figure 4.tif
Figure Figure 3.tif
Figure Figure 2.tif
Figure Figure 1.tif
1486.27.pdf 1486.27.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-07-31
タイトル
タイトル Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord
言語 en
作成者 Kosaka, Yoshinori

× Kosaka, Yoshinori

en Kosaka, Yoshinori

Kin, Hidemichi

× Kin, Hidemichi

en Kin, Hidemichi

Tatetsu, Masaharu

× Tatetsu, Masaharu

en Tatetsu, Masaharu

Uema, Itsuki

× Uema, Itsuki

en Uema, Itsuki

Takayama, Chitoshi

× Takayama, Chitoshi

en Takayama, Chitoshi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 cervical cord
言語 en
主題Scheme Other
主題 GABAergic synapse
言語 en
主題Scheme Other
主題 glutamic acid decarboxylase (GAD)
言語 en
主題Scheme Other
主題 potassium chloride co-transporter 2 (KCC2)
言語 en
主題Scheme Other
主題 vesicular GABA transporter (VGAT)
内容記述
内容記述タイプ Other
内容記述 In the adult brain, gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervical spinal cord. Glutamic acid decarboxylase and GABA were markers for GABA neurons. Vesicular GABA transporter was a marker for GABAergic and glycinergic terminals. Potassium chloride cotransporter 2 was a marker for GABAergic inhibition. We found five points: (1) In the ventral part, GABA neurons were divided into three groups. The first differentiated group sent commissural axons after embryonic day 11 (Ell), but disappeared or changed their transmitter by E15. The second and third differentiated groups were localized in the ventral horn after E12, and sent axons to the ipsilateral marginal zone. There was a distal-to-proximal gradient in varicosity formation in GABAergic axons and a superficial-to-deep gradient in GABAergic synapse formation in the ventral horn; (2) In the dorsal horn, GABA neurons were localized after E13, and synapses were diffusely formed after E15; (3) GABA may be excitatory for several days before synapses formation; (4) There was a ventral-to-dorsal gradient in the development of GABA signaling. The GABAergic inhibitory network may develop in the ventral horn between E15 and E17, and GABA may transiently play crucial roles in inhibitory regulation of the motor system in the mouse fetus; (5) GABA signaling continued to develop after birth, and GABAergic system diminished in the ventral horn.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/46545
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.brainres.2012.10.003
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.brainres.2012.10.003
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0006-8993
収録物名
言語 en
収録物名 Brain Research
書誌情報
巻 1486, 号 27, p. 39-52
戻る
0
views
See details
Views

Versions

Ver.1 2022-02-02 02:13:40.578533
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON

確認


Powered by WEKO3


Powered by WEKO3