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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

Risk factors for progressive sarcopenia 6 months after complete resection of lung cancer : What can thoracic surgeons do against sarcopenia?

http://hdl.handle.net/20.500.12000/46625
http://hdl.handle.net/20.500.12000/46625
2a8e7f48-22ac-49d8-a212-8e7df0138d56
名前 / ファイル ライセンス アクション
iken508text.pdf iken508text.pdf
iken508review.pdf iken508review.pdf
iken508abstract.pdf iken508abstract.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-08-17
タイトル
タイトル Risk factors for progressive sarcopenia 6 months after complete resection of lung cancer : What can thoracic surgeons do against sarcopenia?
言語 en
作成者 Nagata, Masashi

× Nagata, Masashi

en Nagata, Masashi

永田, 仁

× 永田, 仁

ja 永田, 仁

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
主題
言語 en
主題Scheme Other
主題 Lung cancer
言語 en
主題Scheme Other
主題 surgery
言語 en
主題Scheme Other
主題 chronic obstructive pulmonary disease (COPD)
言語 en
主題Scheme Other
主題 gastric cancer
言語 en
主題Scheme Other
主題 operation time
内容記述
内容記述タイプ Other
内容記述 Background: Our previous report described how postoperative progression of sarcopenia predicted longterm prognosis after complete resection of non-small cell lung cancer (NSCLC) in heavy smokers. However, there are currently no effective means to treat progressive sarcopenia. In this study, we aimed to confirm our previous findings in a larger population and to identify factors associated with postoperative progression of sarcopenia to propose possible preventative measures.Methods: This retrospective study analyzed the data of 1,095 patients who underwent curative lobar resection for NSCLC at Kanagawa Cancer Center. We divided patients into four groups according to sex and Brinkman index (BI) above or below 600. Six-month postoperative changes in the skeletal muscle index (SMI) were calculated and associations between clinicopathological factors including changes in SMI and mortality from postoperative 6 months were examined. Only in groups in which postoperative depletion of SMI was shown to be associated with the prognosis, we identified clinicopathological factors associated with depletive SMI.Results: The overall survival rates of 1,095 patients were 89.8% and 82.5% at 3 and 5 years, respectively. The median 6-month change in SMI was –3.4% (range, −22.3% to +17.9%). Multivariate analysis revealed that poor prognosis was independently predicted by a large reduction in the SMI (cut-off value: −10%) in males with a BI ≥600. In 391 heavy-smoking males, factors associated with a postoperative change in SMI ≤−10% were history of other cancers (including gastric cancer) low forced expiratory volume in one second (FEV 1.0, cut-off value: 1,870 mL), and prolonged operation time (cut-off value: 200 minutes).Conclusions: Perioperative measures to prevent postoperative sarcopenia are appropriate for heavy smokers. We obtained some clues regarding countermeasures, one of which may be avoiding long-time operation. Further studies including clinical trials to assess perioperative anti-sarcopenia treatments, are needed.
内容記述タイプ Other
内容記述 学位論文
出版者
言語 ja
出版者 琉球大学
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46625
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.21037/jtd.2020.01.44
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.21037/jtd.2020.01.44
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2072-1439
収録物識別子タイプ ISSN
収録物識別子 2077-6624
収録物名
言語 en
収録物名 Journal of Thoracic Disease
書誌情報
巻 12, 号 3, p. 308-318
学位授与番号
学位授与番号 甲第508号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2020-03-24
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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