WEKO3
アイテム
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However, there are currently no effective means to treat progressive sarcopenia. In this study, we aimed to confirm our previous findings in a larger population and to identify factors associated with postoperative progression of sarcopenia to propose possible preventative measures.Methods: This retrospective study analyzed the data of 1,095 patients who underwent curative lobar resection for NSCLC at Kanagawa Cancer Center. We divided patients into four groups according to sex and Brinkman index (BI) above or below 600. Six-month postoperative changes in the skeletal muscle index (SMI) were calculated and associations between clinicopathological factors including changes in SMI and mortality from postoperative 6 months were examined. Only in groups in which postoperative depletion of SMI was shown to be associated with the prognosis, we identified clinicopathological factors associated with depletive SMI.Results: The overall survival rates of 1,095 patients were 89.8% and 82.5% at 3 and 5 years, respectively. The median 6-month change in SMI was \u20133.4% (range, \u221222.3% to +17.9%). Multivariate analysis revealed that poor prognosis was independently predicted by a large reduction in the SMI (cut-off value: \u221210%) in males with a BI \u2265600. In 391 heavy-smoking males, factors associated with a postoperative change in SMI \u2264\u221210% were history of other cancers (including gastric cancer) low forced expiratory volume in one second (FEV 1.0, cut-off value: 1,870 mL), and prolonged operation time (cut-off value: 200 minutes).Conclusions: Perioperative measures to prevent postoperative sarcopenia are appropriate for heavy smokers. 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Risk factors for progressive sarcopenia 6 months after complete resection of lung cancer : What can thoracic surgeons do against sarcopenia?
http://hdl.handle.net/20.500.12000/46625
http://hdl.handle.net/20.500.12000/466252a8e7f48-22ac-49d8-a212-8e7df0138d56
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iken508text.pdf
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iken508review.pdf
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iken508abstract.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-08-17 | |||||||||
| タイトル | ||||||||||
| タイトル | Risk factors for progressive sarcopenia 6 months after complete resection of lung cancer : What can thoracic surgeons do against sarcopenia? | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Nagata, Masashi
× Nagata, Masashi
× 永田, 仁
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives | |||||||||
| 言語 | en | |||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||
| 権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Lung cancer | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | surgery | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | chronic obstructive pulmonary disease (COPD) | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | gastric cancer | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | operation time | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Background: Our previous report described how postoperative progression of sarcopenia predicted longterm prognosis after complete resection of non-small cell lung cancer (NSCLC) in heavy smokers. However, there are currently no effective means to treat progressive sarcopenia. In this study, we aimed to confirm our previous findings in a larger population and to identify factors associated with postoperative progression of sarcopenia to propose possible preventative measures.Methods: This retrospective study analyzed the data of 1,095 patients who underwent curative lobar resection for NSCLC at Kanagawa Cancer Center. We divided patients into four groups according to sex and Brinkman index (BI) above or below 600. Six-month postoperative changes in the skeletal muscle index (SMI) were calculated and associations between clinicopathological factors including changes in SMI and mortality from postoperative 6 months were examined. Only in groups in which postoperative depletion of SMI was shown to be associated with the prognosis, we identified clinicopathological factors associated with depletive SMI.Results: The overall survival rates of 1,095 patients were 89.8% and 82.5% at 3 and 5 years, respectively. The median 6-month change in SMI was –3.4% (range, −22.3% to +17.9%). Multivariate analysis revealed that poor prognosis was independently predicted by a large reduction in the SMI (cut-off value: −10%) in males with a BI ≥600. In 391 heavy-smoking males, factors associated with a postoperative change in SMI ≤−10% were history of other cancers (including gastric cancer) low forced expiratory volume in one second (FEV 1.0, cut-off value: 1,870 mL), and prolonged operation time (cut-off value: 200 minutes).Conclusions: Perioperative measures to prevent postoperative sarcopenia are appropriate for heavy smokers. We obtained some clues regarding countermeasures, one of which may be avoiding long-time operation. Further studies including clinical trials to assess perioperative anti-sarcopenia treatments, are needed. | |||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 学位論文 | |||||||||
| 出版者 | ||||||||||
| 言語 | ja | |||||||||
| 出版者 | 琉球大学 | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 識別子 | ||||||||||
| 識別子 | http://hdl.handle.net/20.500.12000/46625 | |||||||||
| 識別子タイプ | HDL | |||||||||
| 関連情報 | ||||||||||
| 関連識別子 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.21037/jtd.2020.01.44 | |||||||||
| 関連識別子 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.21037/jtd.2020.01.44 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2072-1439 | |||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2077-6624 | |||||||||
| 収録物名 | ||||||||||
| 言語 | en | |||||||||
| 収録物名 | Journal of Thoracic Disease | |||||||||
| 書誌情報 |
巻 12, 号 3, p. 308-318 |
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| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第508号 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士(医学) | |||||||||
| 言語 | ja | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2020-03-24 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子 | ||||||||||
| 学位授与機関識別子 | 18001 | |||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関名 | ||||||||||
| 学位授与機関名 | 琉球大学 | |||||||||
| 言語 | ja | |||||||||
