{"_buckets": {"deposit": "54f0d610-b752-4f9b-8228-cb640af60d0c"}, "_deposit": {"id": "2012586", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2012586"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02012586", "sets": ["1642838159351", "1642838409905"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "K1 gene transformation activities in AIDS-related and classic type Kaposi\u2019s sarcoma : Correlation with clinical presentation", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Uehara, Karina", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "\u4e0a\u539f, \u4f73\u91cc\u5948", "creatorNameLang": "ja"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u00a9 The Author(s) 2019"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "http://creativecommons.org/licenses/by/4.0/", "subitem_1522651041219": "http://creativecommons.org/licenses/by/4.0/"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi\u2019s sarcoma (KS) and classic KS, but their clinical presentations are different, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosine-based activation motif (ITAM). Since we found the sequence variations in the K1 gene of KSHV isolated from AIDS-related KS and classic KS, we hypothesized that the transformation activity of the K1 gene contributes to the different clinical presentations. To evaluate our hypothesis, we compared the transformation activities of the K1 gene between AIDS-related KS and classic KS. We also analyzed ITAM activities and the downstream AKT and NF-\u03baB. We found that the transformation activity of AIDS-related K1 was greater than that of classic K1, and that AIDS-related K1 induced higher ITAM activity than classic K1, causing more potent Akt and NF-\u03baB activities. K1 downregulation by siRNA in AIDS-related K1 expressing cells induced a loss of transformation properties and decreased both Akt and NF-\u03baB activities, suggesting a correlation between the transformation activity of K1 and ITAM signaling. Our study indicates that the increased transformation activity of AIDS-related K1 is associated with its clinical aggressiveness, whereas the weak transformation activity of classic type K1 is associated with a mild clinical presentation and spontaneous regression. The mechanism of spontaneous regression of classic KS may provide new therapeutic strategy to cancer.", "subitem_description_type": "Other"}, {"subitem_description": "\u5b66\u4f4d\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "University of the Ryukyus"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/46707"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "2045-2322"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "scientific reports"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "6416", "bibliographicVolumeNumber": "9"}]}, "item_1617187087799": {"attribute_name": "Dissertation Number", "attribute_value_mlt": [{"subitem_1551256171004": "\u7532\u7b2c505\u53f7"}]}, "item_1617187112279": {"attribute_name": "Degree Name", "attribute_value_mlt": [{"subitem_1551256126428": "\u535a\u58eb(\u533b\u5b66)", "subitem_1551256129013": "ja"}]}, "item_1617187136212": {"attribute_name": "Date Granted", "attribute_value_mlt": [{"subitem_1551256096004": "2020-03-24"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1038/s41598-019-42763-0"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1038/s41598-019-42763-0"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "iken505sbstract.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "abstract", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012586/files/iken505sbstract.pdf"}, "version_id": "00671303-00fd-4b3c-8715-93b1a6d0e56c"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 1, "filename": "iken505text.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012586/files/iken505text.pdf"}, "version_id": "a2d054e7-2596-418a-9081-eb45b1f63515"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 2, "filename": "iken505review.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "other", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012586/files/iken505review.pdf"}, "version_id": "97961256-6806-43d7-8185-75380c57f608"}]}, "item_1617944105607": {"attribute_name": "Degree Grantor", "attribute_value_mlt": [{"subitem_1551256015892": [{"subitem_1551256027296": "18001", "subitem_1551256029891": "kakenhi"}], "subitem_1551256037922": [{"subitem_1551256042287": "\u7409\u7403\u5927\u5b66", "subitem_1551256047619": "ja"}]}]}, "item_title": "K1 gene transformation activities in AIDS-related and classic type Kaposi\u2019s sarcoma : Correlation with clinical presentation", "item_type_id": "15", "owner": "1", "path": ["1642838159351", "1642838409905"], "permalink_uri": "http://hdl.handle.net/20.500.12000/46707", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-09-15"}, "publish_date": "2020-09-15", "publish_status": "0", "recid": "2012586", "relation": {}, "relation_version_is_last": true, "title": ["K1 gene transformation activities in AIDS-related and classic type Kaposi\u2019s sarcoma : Correlation with clinical presentation"], "weko_shared_id": -1}