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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma : Correlation with clinical presentation

http://hdl.handle.net/20.500.12000/46707
http://hdl.handle.net/20.500.12000/46707
e2351caa-b19a-4306-8c7a-93eccb465617
名前 / ファイル ライセンス アクション
iken505sbstract.pdf iken505sbstract.pdf
iken505text.pdf iken505text.pdf
iken505review.pdf iken505review.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-09-15
タイトル
タイトル K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma : Correlation with clinical presentation
言語 ja
作成者 Uehara, Karina

× Uehara, Karina

en Uehara, Karina

上原, 佳里奈

× 上原, 佳里奈

ja 上原, 佳里奈

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © The Author(s) 2019
内容記述
内容記述タイプ Other
内容記述 Kaposi’s sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi’s sarcoma (KS) and classic KS, but their clinical presentations are different, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosine-based activation motif (ITAM). Since we found the sequence variations in the K1 gene of KSHV isolated from AIDS-related KS and classic KS, we hypothesized that the transformation activity of the K1 gene contributes to the different clinical presentations. To evaluate our hypothesis, we compared the transformation activities of the K1 gene between AIDS-related KS and classic KS. We also analyzed ITAM activities and the downstream AKT and NF-κB. We found that the transformation activity of AIDS-related K1 was greater than that of classic K1, and that AIDS-related K1 induced higher ITAM activity than classic K1, causing more potent Akt and NF-κB activities. K1 downregulation by siRNA in AIDS-related K1 expressing cells induced a loss of transformation properties and decreased both Akt and NF-κB activities, suggesting a correlation between the transformation activity of K1 and ITAM signaling. Our study indicates that the increased transformation activity of AIDS-related K1 is associated with its clinical aggressiveness, whereas the weak transformation activity of classic type K1 is associated with a mild clinical presentation and spontaneous regression. The mechanism of spontaneous regression of classic KS may provide new therapeutic strategy to cancer.
内容記述タイプ Other
内容記述 学位論文
出版者
言語 en
出版者 University of the Ryukyus
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46707
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-019-42763-0
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-019-42763-0
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2045-2322
収録物名
言語 en
収録物名 scientific reports
書誌情報
巻 9, 号 6416
学位授与番号
学位授与番号 甲第505号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2020-03-24
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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