{"_buckets": {"deposit": "0f6fa085-4d38-4cf1-baad-6c8c6ec32549"}, "_deposit": {"id": "2012590", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2012590"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02012590", "sets": ["1642838159351", "1642838409905"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T\u2010cell leukemia/lymphoma", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Morichika, Kazuho", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "\u68ee\u8fd1, \u4e00\u7a42", "creatorNameLang": "ja"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u00a9 2019 The Authors Cancer Science published by John Wiley \u0026 Sons Australia, Ltd on behalf of Japanese Cancer Association."}, {"subitem_1522650717957": "en", "subitem_1522651041219": "Creat ive Commo ns Attri bution-NonCo mmercial License"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by-nc/4.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by-nc/4.0/"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "adult T\u2010cell leukemia/lymphoma"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "immunohistochemistry"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "phosphorylated STAT3"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Shimoyama classification"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "STAT3 mutation"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Adult T\u2010cell leukemia/lymphoma (ATLL) is a mature T\u2010cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK\u2010STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P \u003c .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression\u2010free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.", "subitem_description_type": "Other"}, {"subitem_description": "\u5b66\u4f4d\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "University of the Ryukyus"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/46668"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1347-9032"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1349-7006"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Cancer Science"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "9", "bibliographicPageEnd": "2991", "bibliographicPageStart": "2982", "bibliographicVolumeNumber": "110"}]}, "item_1617187087799": {"attribute_name": "Dissertation Number", "attribute_value_mlt": [{"subitem_1551256171004": "\u7532\u7b2c501\u53f7"}]}, "item_1617187112279": {"attribute_name": "Degree Name", "attribute_value_mlt": [{"subitem_1551256126428": "\u535a\u58eb(\u533b\u5b66)", "subitem_1551256129013": "ja"}]}, "item_1617187136212": {"attribute_name": "Date Granted", "attribute_value_mlt": [{"subitem_1551256096004": "2020-03-24"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1111/cas.14114"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1111/cas.14114"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "iken501text.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012590/files/iken501text.pdf"}, "version_id": "e1fb006e-6d8d-4ea2-b153-8b502cc57cc3"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 1, "filename": "iken501review.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "other", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012590/files/iken501review.pdf"}, "version_id": "fda3a6a6-6bde-4e07-a2eb-f8caa3bdad29"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 2, "filename": "iken501abstract.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "abstract", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012590/files/iken501abstract.pdf"}, "version_id": "5ac78474-2034-44ca-9aa5-8b944507cbee"}]}, "item_1617944105607": {"attribute_name": "Degree Grantor", "attribute_value_mlt": [{"subitem_1551256015892": [{"subitem_1551256027296": "18001", "subitem_1551256029891": "kakenhi"}], "subitem_1551256037922": [{"subitem_1551256042287": "\u7409\u7403\u5927\u5b66", "subitem_1551256047619": "ja"}]}]}, "item_title": "Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T\u2010cell leukemia/lymphoma", "item_type_id": "15", "owner": "1", "path": ["1642838159351", "1642838409905"], "permalink_uri": "http://hdl.handle.net/20.500.12000/46668", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-09-14"}, "publish_date": "2020-09-14", "publish_status": "0", "recid": "2012590", "relation": {}, "relation_version_is_last": true, "title": ["Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T\u2010cell leukemia/lymphoma"], "weko_shared_id": -1}