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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T‐cell leukemia/lymphoma

http://hdl.handle.net/20.500.12000/46668
http://hdl.handle.net/20.500.12000/46668
a46a2a59-4888-491d-9a9b-6d805f9fbd57
名前 / ファイル ライセンス アクション
iken501text.pdf iken501text.pdf
iken501review.pdf iken501review.pdf
iken501abstract.pdf iken501abstract.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-09-14
タイトル
タイトル Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T‐cell leukemia/lymphoma
言語 ja
作成者 Morichika, Kazuho

× Morichika, Kazuho

en Morichika, Kazuho

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森近, 一穂

× 森近, 一穂

ja 森近, 一穂

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © 2019 The Authors Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
権利情報
言語 en
権利情報 Creat ive Commo ns Attri bution-NonCo mmercial License
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc/4.0/
権利情報 https://creativecommons.org/licenses/by-nc/4.0/
主題
言語 ja
主題Scheme Other
主題 adult T‐cell leukemia/lymphoma
主題
言語 en
主題Scheme Other
主題 immunohistochemistry
主題
言語 en
主題Scheme Other
主題 phosphorylated STAT3
主題
言語 en
主題Scheme Other
主題 Shimoyama classification
主題
言語 en
主題Scheme Other
主題 STAT3 mutation
内容記述
内容記述タイプ Other
内容記述 Adult T‐cell leukemia/lymphoma (ATLL) is a mature T‐cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK‐STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P < .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression‐free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.
内容記述
内容記述タイプ Other
内容記述 学位論文
出版者
言語 en
出版者 University of the Ryukyus
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46668
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.14114
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/cas.14114
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-9032
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-7006
収録物名
言語 en
収録物名 Cancer Science
書誌情報
巻 110, 号 9, p. 2982-2991, 発行日 2019-06-25
学位授与番号
学位授与番号 甲第501号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2020-03-24
学位授与機関
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名 琉球大学
言語 ja
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