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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay

http://hdl.handle.net/20.500.12000/46669
http://hdl.handle.net/20.500.12000/46669
a5ad77ae-55c7-4f89-a138-76d8cecfeff8
名前 / ファイル ライセンス アクション
iken506text.pdf iken506text.pdf
iken506review.pdf iken506review.pdf
iken506abstract.pdf iken506abstract.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-09-14
タイトル
タイトル A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay
言語 en
作成者 Hokama, Noboru

× Hokama, Noboru

en Hokama, Noboru

外間, 登

× 外間, 登

ja 外間, 登

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 en
主題Scheme Other
主題 xanthine oxidase (XO)
言語 en
主題Scheme Other
主題 graft-versus-host disease (GVHD)
言語 en
主題Scheme Other
主題 allogeneic hematopoietic stem cell transplantation (allo-HSCT)
言語 en
主題Scheme Other
主題 hematological malignancy
言語 en
主題Scheme Other
主題 uric acid
内容記述
内容記述タイプ Other
内容記述 Xanthine oxidase (XO) is a rate limiting enzyme for production of uric acid. The activity of XO in plasma is reported to elevate in patients with familial hypercholesterolaemia and cardiovascular diseases. Such an increase in plasma XO activity was also demonstrated in patients with a variety of cancers. However, there have been few reports evaluating the plasma XO activity in patients with hematological malignancies during course of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chemotherapies. We explored the relationship between plasma XO activity and clinical symptoms/biochemical parameters in 10 patients with hematological malignancies. The XO activity was measured by a highsensitivity fluorescence technique. Plasma XO activity in hematological malignancies before chemotherapy was not elevated compared to healthy subjects. In patients receiving allo-HSCT, no apparent increase in plasma XO activity was observed at the appearance of graft-versus-host disease (GVHD). Noticeably, however, the value of plasma XO activity was closely associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies. To our knowledge, the present study is the first to investigate consecutively the value in plasma XO activity in patients with hematological malignancies. Despite small numbers analyzed, value of plasma XO activity was tightly associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies, suggesting that the value may reflect liver damage related with a variety of therapeutic interventions.
内容記述タイプ Other
内容記述 学位論文
出版者
言語 en
出版者 University of the Ryukyus
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46669
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/hon.2659
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/hon.2659
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0278-0232
収録物識別子タイプ ISSN
収録物識別子 1099-1069
収録物名
言語 en
収録物名 Hematological Oncology
書誌情報
巻 37, 号 4, p. 527-530
学位授与番号
学位授与番号 甲第506号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2020-03-24
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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