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アイテム
Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer
http://hdl.handle.net/20.500.12000/46671
http://hdl.handle.net/20.500.12000/466716749fcaa-3e8e-470d-b47b-ac5bf01c4d61
| 名前 / ファイル | ライセンス | アクション |
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iken507digest.pdf
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iken507review.pdf
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iken507abstract.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-09-14 | |||||||||
| タイトル | ||||||||||
| タイトル | Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Abe, Norie
× Abe, Norie
× 阿部, 典恵
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| アクセス権 | ||||||||||
| アクセス権 | embargoed access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Tumor-infiltrating lymphocyte (TIL) | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Image analysis | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | HER2 | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Pathological complete response (pCR) | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | As visual quantification of the density of tumor-infiltrating lymphocytes (TILs) lacks in precision, digital image analysis (DIA) approach has been applied in order to improve. In several studies, TIL density has been examined on hematoxylin and eosin (HE)-stained sections using DIA. The aim of the present study was to quantify TIL density on HE sections of core needle biopsies using DIA and investigate its association with clinicopathological parameters and pathological response to neoadjuvant chemotherapy in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The study cohort comprised of patients with HER2-positive breast cancer, all treated with neoadjuvant anti-HER2 therapy. DIA software applying machine learning-based classification of epithelial and stromal elements was used to count TILs. TIL density was determined as the number of TILs per square millimeter of stromal tissue. Median TIL density was 1287/mm^2 (range, 123–8101/mm^2). A high TIL density was associated with higher histological grade (P = 0.02), estrogen receptor negativity (P = 0.036), and pathological complete response (pCR) (P < 0.0001). In analyses using receiver operating characteristic curves, a threshold TIL density of 2420/mm^2 best discriminated pCR from non-pCR. In multivariate analysis, high TIL density (> 2420/mm^2) was significantly associated with pCR (P < 0.0001). Our results indicate that DIA can assess TIL density quantitatively, machine learning-based classification algorithm allowing determination of TIL density as the number of TILs per unit area, and TIL density established by this method appears to be an independent predictor of pCR in HER2-positive breast cancer. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 学位論文 | |||||||||
| 出版者 | ||||||||||
| 出版者 | University of the Ryukyus | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 識別子 | ||||||||||
| 識別子 | http://hdl.handle.net/20.500.12000/46671 | |||||||||
| 識別子タイプ | HDL | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1007/s00428-019-02730-6 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1007/s00428-019-02730-6 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0945-6317 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1432-2307 | |||||||||
| 収録物名 | ||||||||||
| 収録物名 | Virchows Archiv | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
巻 476, p. 701-709, 発行日 2019-12-23 |
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| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第507号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士(医学) | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2020-03-24 | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 琉球大学 | |||||||||
