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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 26巻3・4号
  1. 部局別インデックス
  2. その他

[総説]CYP2C19に関連したomeprazoleの代謝と体内動態について

http://hdl.handle.net/20.500.12000/0002015564
http://hdl.handle.net/20.500.12000/0002015564
370e27e9-31e5-43ed-b034-e0c319886917
名前 / ファイル ライセンス アクション
v26p105.pdf v26p105.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-02-23
タイトル
タイトル [総説]CYP2C19に関連したomeprazoleの代謝と体内動態について
言語 ja
タイトル
タイトル The Metabolism and Pharmacokinetics of Omeprazole in Relation to CYP2C19
言語 en
作成者 宇野, 司

× 宇野, 司

ja 宇野, 司

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Uno, Tsukasa

× Uno, Tsukasa

en Uno, Tsukasa

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 omeprazole
主題
言語 en
主題Scheme Other
主題 CYP2C19
主題
言語 en
主題Scheme Other
主題 hydroxylation index
主題
言語 en
主題Scheme Other
主題 extensive metabolizers
主題
言語 en
主題Scheme Other
主題 poor metabolizers
内容記述
内容記述タイプ Other
内容記述 Omeprazole is one of the most widely used proton pump inhibitors for the treatment of gastric acid-related disorders. Omeprazole is completely metabolized, predominantly to 5-hydroxyomeprazole catalyzed by CYP2C19, which shows genetically determined polymorphism, yielding extensive metabolizers(EMs) and poor metabolizers(PMs). The CYP2C19 genetic polymorphism results in a significant difference in the area under the plasma concentration-time curve(AUC)of omeprazole, and AUC of omeprazole in PMs was significantly higher than that in EMs. The CYP2C19 genotyping therefore is a useful tool for guiding treatment effect in patients with various peptic diseases because the acid suppressive effect of omeprazole is also reported to correlate with AUC level. For the better treatment of gastric acid-related disorders, doses and dosing schemes of omeprazole should be optimized based on CYP2C19 genotype status.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 26, 号 3・4, p. 105-112, 発行日 2007
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