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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 26巻1・2号
  1. 部局別インデックス
  2. その他

[総説]細菌性赤痢の病態形成における感染と宿主応答の分子機構

http://hdl.handle.net/20.500.12000/0002015572
http://hdl.handle.net/20.500.12000/0002015572
766e7516-fc61-4b4e-b36c-ce454088691e
名前 / ファイル ライセンス アクション
v26p9.pdf v26p9.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-02-23
タイトル
タイトル [総説]細菌性赤痢の病態形成における感染と宿主応答の分子機構
言語 ja
作成者 鈴木, 敏彦

× 鈴木, 敏彦

ja 鈴木, 敏彦

Suzuki, Toshihiko

× Suzuki, Toshihiko

en Suzuki, Toshihiko

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Shigella
言語 en
主題Scheme Other
主題 pathogemcity
言語 en
主題Scheme Other
主題 actm polymerization
言語 en
主題Scheme Other
主題 inflammation
言語 en
主題Scheme Other
主題 caspase-1
内容記述
内容記述タイプ Other
内容記述 Shigella are highly adapted human pathogens that cause bacillary dysentery (also referred to shigellosis). When the pathogen reaches the human colon, bacteria translocate through the epithelial barrier by way of the M Cells that overlay the solitary lymphoid nodules. Once it reaches the underlying M cells, Shigella infects the resident macrophages and induces proinflammatory cell death with interleukin-1 $ \beta $ release. Meanwhile, a bacterium release from the macrophages enters enterocytes via the basolateral surface by directing membrane ruffling and macropmocytosis, The bacterium is surrounded by a phagocytic vacuole; however, it immediately disrupts the membrane to escape into the cytoplasm, where it can multiply and move by inducing actin polymerization at one pole of the bacterium, allowing intracellular spread within the cytoplasm as well as into adjacent epithelial cells. The prominent pathogenic feature of Shigella is their ability to invade a variety of host cells, including epithelial cells, macrophages, and dendritic cells, which leads to severe inflammatory responses in intestinal tissue. Thus, the ability of Shigella spp. to infect host cells, including the continuous intra-and intercellular spreading, is essential for leading to bacillary dysentery. Recently, our molecular and cell biological approaches to the study of linkages between the bacterial factors and host cellular ligands have shed light on the molecular basis of actin polymerization and of proinflammatory responses directed by intracellular bacteria. Here, we summarize and discuss the present model for the interaction between bacteria and host cells on Shigella infection.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 26, 号 1・2, p. 9-18
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