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[総説]破裂脳動脈瘤塞栓術後のくも膜下出血に伴う脳血攣縮に対する新しい治療法の開発
http://hdl.handle.net/20.500.12000/0002015581
http://hdl.handle.net/20.500.12000/00020155813222423b-3021-462a-a9de-53bce7df4cba
名前 / ファイル | ライセンス | アクション |
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v27p87.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2010-02-23 | |||||||||
タイトル | ||||||||||
タイトル | [総説]破裂脳動脈瘤塞栓術後のくも膜下出血に伴う脳血攣縮に対する新しい治療法の開発 | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | Effect of microcatheter intrathecal urokinase infusion into the cisterna magna on cebral vasospasm after coil embolization for ruptured aneurysms | |||||||||
言語 | en | |||||||||
作成者 |
甲斐, 豊
× 甲斐, 豊
× Yutaka, Kai
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cerebral | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | neurysm | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cisterna magna | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | embolization | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | urokinase | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | vasospasm | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | To prevent vasospasm in patients with ruptured aneurysms who had undergone Guglielmi detachable coil (GDC) placement, we developed our ITSUKI (intrathecal simple administration of urokinase infusion) therapy and kit (ITSUKIT) for performing of ITSUKI.Here we present the effectiveness of this therapy in preventing the severity of ischemic neurological deficits attributable to vasospasm. After evaluating the effectiveness of ITSUKI therapy in a canine subarachnoid hemorrhage (SAH) model, we performed clinical trials.At 24 hr after SAH induction, we injected urokinase (UK. 1000 IU/kg) into the cisterna magna (CM) or lumbar sac (LS) of dogs via a microcatheter inserted in the lumbar region. We then obtained serial angiograms over a 14-day period and chronologically examined the changes in the mean diameter of the basilar artery (BA) to determine the effect of different injection sites on vasospasm prevention. In our canine SAH model, the administration of UK into the CM was significantly more effective for preventing cerebral vasospasms than was administration into the LS. We enrolled 20 patients with ruptured intracranial aneurysms who were eligible for coil embolization with (n=10) or without (n=10) ITSUKI therapy. There were no side effects or adverse reactions attributable to ITSUKI therapy. Symptomatic vasospasm occurred in 1 (10.0%) patients with and 5 (50.0%) without ITSUKI therapy; the difference was significant (p<0.05). Although the mortality rate did not differ between the 2 groups, patients with ITSUKI therapy had significantly better outcomes than those without (p<0.05). No complication was observed according to ITSUKIT and it was useful for ITSUKI therapy. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346-888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0289-1530 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 27, 号 3・4, p. 87-91, 発行日 2008 |