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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 27巻3・4号
  1. 部局別インデックス
  2. その他

[総説]破裂脳動脈瘤塞栓術後のくも膜下出血に伴う脳血攣縮に対する新しい治療法の開発

http://hdl.handle.net/20.500.12000/0002015581
http://hdl.handle.net/20.500.12000/0002015581
3222423b-3021-462a-a9de-53bce7df4cba
名前 / ファイル ライセンス アクション
v27p87.pdf v27p87.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-02-23
タイトル
タイトル [総説]破裂脳動脈瘤塞栓術後のくも膜下出血に伴う脳血攣縮に対する新しい治療法の開発
言語 ja
作成者 甲斐, 豊

× 甲斐, 豊

ja 甲斐, 豊

Yutaka, Kai

× Yutaka, Kai

en Yutaka, Kai

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 cerebral
言語 en
主題Scheme Other
主題 neurysm
言語 en
主題Scheme Other
主題 cisterna magna
言語 en
主題Scheme Other
主題 embolization
言語 en
主題Scheme Other
主題 urokinase
言語 en
主題Scheme Other
主題 vasospasm
内容記述
内容記述タイプ Other
内容記述 To prevent vasospasm in patients with ruptured aneurysms who had undergone Guglielmi detachable coil (GDC) placement, we developed our ITSUKI (intrathecal simple administration of urokinase infusion) therapy and kit (ITSUKIT) for performing of ITSUKI.Here we present the effectiveness of this therapy in preventing the severity of ischemic neurological deficits attributable to vasospasm. After evaluating the effectiveness of ITSUKI therapy in a canine subarachnoid hemorrhage (SAH) model, we performed clinical trials.At 24 hr after SAH induction, we injected urokinase (UK. 1000 IU/kg) into the cisterna magna (CM) or lumbar sac (LS) of dogs via a microcatheter inserted in the lumbar region. We then obtained serial angiograms over a 14-day period and chronologically examined the changes in the mean diameter of the basilar artery (BA) to determine the effect of different injection sites on vasospasm prevention. In our canine SAH model, the administration of UK into the CM was significantly more effective for preventing cerebral vasospasms than was administration into the LS. We enrolled 20 patients with ruptured intracranial aneurysms who were eligible for coil embolization with (n=10) or without (n=10) ITSUKI therapy. There were no side effects or adverse reactions attributable to ITSUKI therapy. Symptomatic vasospasm occurred in 1 (10.0%) patients with and 5 (50.0%) without ITSUKI therapy; the difference was significant (p<0.05). Although the mortality rate did not differ between the 2 groups, patients with ITSUKI therapy had significantly better outcomes than those without (p<0.05). No complication was observed according to ITSUKIT and it was useful for ITSUKI therapy.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 27, 号 3・4, p. 87-91
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