{"_buckets": {"deposit": "0a4fb254-53de-41e5-88e1-955376828fbb"}, "_deposit": {"id": "2015595", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2015595"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02015595", "sets": ["1642838223333", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[総説]Rational Design to Develop Antithrombotic Drugs from the Relationship between the Structure and Function of $ \\alpha $ thrombin", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sunagawa, Masanori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakamura, Mariko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shimada, Seiji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tengan, Hiroatsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takara, Shigeru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yoshioka, Miwa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakamura, Kazunao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasutaka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Motomura, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tamaki, Minao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uehara, Ken", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohta, Shigeto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Bae, Maen", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakasone, Toshiyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kosugi, Tadayoshi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "antithrombotic drug"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "native thrombin"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "clot-bound thrombin"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "structure-function relationship"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Many protease inhibitors in the circulating blood inhibit the activity of $ \\alpha $-thrombin. Inhibition of $ \\alpha $-thrombin by antithrombins is attributable to the characteristics of structural relationships between $ \\alpha $-thrombin and antithrombins. The characteristic structures of $ \\alpha $-thrombin include loop 60, exosites 1 and 2, hydrophobic pocket, primary specificity pocket, and active site (catalytic triad). Functions of these structures have been clarified by enzyme-substrate reaction and X-ray and NMR-crystallographic analyses. For developing antithrombine drugs that is safely and effectively used for clinical treatment of thrombotic diseases, the precise understandings of relationship between structure and function of α-thrombm are required. Although it has been evidenced that clot-bound thrombm plays more important role in pathophysiological conditions than native (free) thrombin, the structure and function of clot-bound thrombin remains to be clarified. Understanding the structure and function of clot-bound thrombm would provide a potential therapeutic strategy to develop novel antithrombin drugs, which control the activity of the clot-bound thrombin in the circulating blood. In this review paper, first of all we summarized the structure-function relationships based on the studies on native thrombin and mutant thrombin. Secondary, we summarized the mechanism for thrombin receptor activation by $ \\alpha $-thrombin and thrombin receptor agonist peptide (TRAP). Finally, we demonstrated our resuits of the studies on the characteristics of clot-bound thrombin", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346-888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3・4", "bibliographicPageEnd": "109", "bibliographicPageStart": "95", "bibliographicVolumeNumber": "25"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v25p95.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2015595/files/v25p95.pdf"}, "version_id": "f0902ae8-092b-4a85-b94c-e9286313c108"}]}, "item_title": "[総説]Rational Design to Develop Antithrombotic Drugs from the Relationship between the Structure and Function of $ \\alpha $ thrombin", "item_type_id": "15", "owner": "1", "path": ["1642838223333", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002015595", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-02-23"}, "publish_date": "2010-02-23", "publish_status": "0", "recid": "2015595", "relation": {}, "relation_version_is_last": true, "title": ["[総説]Rational Design to Develop Antithrombotic Drugs from the Relationship between the Structure and Function of $ \\alpha $ thrombin"], "weko_shared_id": -1}
[総説]Rational Design to Develop Antithrombotic Drugs from the Relationship between the Structure and Function of $ \alpha $ thrombin
http://hdl.handle.net/20.500.12000/0002015595
http://hdl.handle.net/20.500.12000/0002015595