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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 25巻3・4号
  1. 部局別インデックス
  2. その他

[総説]Ca^<2+>/ カルモデュリン依存性タンパク質リン酸化反応による細胞機能の制御

http://hdl.handle.net/20.500.12000/0002015596
http://hdl.handle.net/20.500.12000/0002015596
02ef05c8-8d0b-47aa-a81d-4b1e85459382
名前 / ファイル ライセンス アクション
v25p111.pdf v25p111.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-02-23
タイトル
タイトル [総説]Ca^<2+>/ カルモデュリン依存性タンパク質リン酸化反応による細胞機能の制御
言語 ja
作成者 山本, 秀幸

× 山本, 秀幸

ja 山本, 秀幸

Yamamoto, Hideyuki

× Yamamoto, Hideyuki

en Yamamoto, Hideyuki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Ca^<2+>
言語 en
主題Scheme Other
主題 calmodulin
言語 en
主題Scheme Other
主題 CaM kinase II
言語 en
主題Scheme Other
主題 neurons
言語 en
主題Scheme Other
主題 Alzheimer's disease
内容記述
内容記述タイプ Other
内容記述 Intracellular Ca^<2+> has been reported to play a critical role in various cellular functions. Many effects of Ca^<2+> are mediated through calmodulin (CaM), and the effects of Ca^<2+>/CaM may be mediated by Ca^<2+>/CaM-dependent protein kinase II (CaM kinase II). Four subunits of CaM kinase II are encoded by distinct genes, and various isoforms of these subunits exist as different splicing variants. In this review, I will focus on the subcellular localizations of major isoforms in neurons and pancreatic $ \beta $ cells and their physiological functions. CaM kinase II is abundant in neurons, comprising 1-2% of the total protein concentration. $ \alpha $ isoform is the most abundant isoform of CaM kinase II in neurons in hippocampal CA1 region. In this region, $ \alpha $ isoform is distributed in the cytoplasm in postsynapse and translocates to postsynaptic density (PSD) following its activation. There are many evidence demonstrating that $ \alpha $ isoform in PSD plays an imiportant role in synaptic plasticity. $ \alpha $B and $ \delta $3 isoforms contain a nuclear localization signal and are localized in the nucleus. Both lsoforms are involved in gene expression. In addition to PSD, $ \alpha $ isoform is associated with synaptic vesicle membranes in presynapse. In the case of insulinoma cells derived from pancreatic $ \beta $ cells, we found that $ \delta 2 isoform is associated with insulin secretory granule membranes. $ \alpha $ isoform and $ \delta $ 2 isoform are involved in neurotransmitter release and insulin secretion, respectively. These results suggest that each isoform is localized in the specific regions in the cells to play an important role in the specific cellular functions. Interestingly, the accumulation of $ \alpha $ isoform has been noted in neuronal soma in Alzheimer's disease brain. Our recent data suggest that $ \alpha $ isoform hyperphosphorylates tau in neuronal soma in Alzheimer's disease brain. Therefore, disturbance of physiological functions of $ \alpha $ isoiorm may be related to the pathophysiology of Alzheimer's disease.
内容記述タイプ Other
内容記述 calmodulin
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 25, 号 3・4, p. 111-122
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