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[総説]新しい前立腺がんマーカー
http://hdl.handle.net/20.500.12000/0002015624
http://hdl.handle.net/20.500.12000/00020156244df2e8d2-0d47-412b-9636-042beca3d689
名前 / ファイル | ライセンス | アクション |
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2010-04-28 | |||||||||
タイトル | ||||||||||
タイトル | [総説]新しい前立腺がんマーカー | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | A New Marker for Prostate Cancer | |||||||||
言語 | en | |||||||||
作成者 |
斎藤, 誠一
× 斎藤, 誠一
× Saito, Seiichi
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Prostate cancer | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | PSA | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | marker | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Prostate-specific antigen (PSA) has been widely used for detection and diagnosis of early prostate cancer. However, PSA has problems with specificity and does not reflect grade of malignancy. In addition, PSA has no cut-off value because the prevalence of prostate cancer was reported to be 15% among men with PSA 4 ng/mL or less. Therefore, a new serum marker to compensate for the problems of PSA is urgently required. In an attempt to search a novel marker, we focused on the glycosyl epitope, $ \beta $1, 4-GalNAcDSLc_4 , to which monoclonal antibody (mAb) RM2 was established using renal cell carcinoma cell line, based on the assumption that the hybrid structure of the glycosyl epotope is associated with the nature of prostate cancer. By immunohistochemistry using radical prostatectomy specimens,we found RM2 reacted to prostate cancer cells, reflecting grade of malignancy, whereas RM2 had no reactivity to benign prostatic hyperplasia. RM2 showed preferential reactivity toward haptoglobin-beta chain derived from prostate cancer than that from benign prostatic diseases. Haptoglobin-beta chain defined by RM2 (Hp-beta-RM2) in serum had sensitivity of 87% and specificity of 84% for detecting early prostate cancer among men with PSA value < 10 ng/mL. Hp-beta-RM2 is a novel serum marker that may be useful for detection of early prostate cancer. Furthermore, serum level of Hp-beta-RM2 may predict PSA failure after radical prostatectomy, although the number of patients examined is small. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346-888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0289-1530 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 28, 号 1・2, p. 9-16, 発行日 2009 |