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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球大学医学会雑誌
  4. 9巻3-4号
  1. 部局別インデックス
  2. その他

[原著]ENHANCEMENT OF HEPATIC MICROSOMALAMINO・PYRINE N-DEMETHYLATION BY NEUTRAL SALTS

http://hdl.handle.net/20.500.12000/0002015756
http://hdl.handle.net/20.500.12000/0002015756
2a859082-da34-46e5-8ebb-6566af4e46f8
名前 / ファイル ライセンス アクション
v9p151.pdf v9p151.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-06-30
タイトル
タイトル [原著]ENHANCEMENT OF HEPATIC MICROSOMALAMINO・PYRINE N-DEMETHYLATION BY NEUTRAL SALTS
言語 ja
作成者 Aniya, Yoko

× Aniya, Yoko

en Aniya, Yoko

Matsusaki, Kichihiko

× Matsusaki, Kichihiko

en Matsusaki, Kichihiko

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 ja
主題Scheme Other
主題 N-demethylation
言語 ja
主題Scheme Other
主題 cytochrome P-450
内容記述
内容記述タイプ Other
内容記述 Enhancement of aminopyrine N-demethylation by neutral salts was kinetically studied using hepatic microsomes from nontreated, phenobarbital- or 3-methylcholanthrene-treated rats. Aminopyrine N-demethylation was increased 3-fold by 0.4 M sodium sulfate in nontreated or 3-methylcholanthrene-treated microsomes. On the other hand, the enhancement was 1.7-fold in phenobarbital-treated microsomes. Lineweaver-Burk plots of aminopyrine N-demethylase were not linear in nontreated microsomes and two Km values (2X10^<-3>M, 5X10^<-4>M) were obtained. However, the addition of neutral salts to the microsomes brought on a linear Lineweaver-Burk plots of the demethylation and only one km, which was less than 2X10^<-3>M. Aminopyrine-induced difference spectra of the microsomes were increased by the addition of neutral salts, and double reciprocal plots of the spectrum vs aminopyrine concentration were linear, though the plots were not linear in absence of the salts. Dissociation constant (Ks) values were also decreased by the addition of neutral salts corresponding enhancement of the demethylation, as were the km values. In phenobarbital or 3-methylcholanthrene-treated microsomes one Km was obtained regardless of the presence or absence of sodium sulfate, though Km of the demethylase in the former microsomes was higher than that in the latter after addition of the salt. These results suggest that there are multiple forms of aminopyrine N-demethylase in nontreated and 3-methylcholanthrene -treated microsomes and some of them slightly contribute to the demethylation in normal condition but exhibite the demethylase activity by addition of the salts. Phenobarbital may induce the aminopyrine N-demethylase capable of demethylating aminopyrine in normal condition resulted in less enhancement of the demethylation by the salts.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球大学医学部
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10027430
収録物名
言語 ja
収録物名 琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal
書誌情報
巻 9, 号 3-4, p. 151-159, 発行日 1986
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