Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2010-06-30 |
タイトル |
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タイトル |
[原著]再発悪性グリオ-マに対するIFN-β局所投与とACNU動注療法の試み |
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言語 |
ja |
タイトル |
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タイトル |
Combined Treatment of Local Injection IFN-β and Intracarotid Injection of ACNU to Recurrent Malignant Gliomas |
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言語 |
en |
作成者 |
仲宗根, 進
六川, 二郎
高良, 英一
銘苅, 晋
石川, 泰成
久田, 均
Nakasone, Susumu
Mukawa, Jiro
Takara, Eiichi
Mekaru, Susumu
Ishikawa, Yasunari
Kuda, Hitoshi
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
ja |
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権利情報 |
琉球医学会 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Five cases of recurrent malignant gliomas were treated with local injection of interferon- βcombined with intracarotid injection of 1-(4-amino 2methy1-5-pyrimidinyl)methy1 -3-(2-chlor∝thy1)-3-nitrosourea hydrochloride(ACNU). All patients had been already treated with intravenous injection of IFN-β and/or ACNU as well as conventional radiotherapy after surgery. IFN-β(3×10^6 IU, 3 times a week) was locally injected through a catheter placed into tumor-removed cavity. ACNU (100mg/6weeks) was injected into the carotid artery following osmotic blood brain barrier modification produced by arterial injetion of 20% 200ml mannitol. Multiple intracranial lesions were checked with contrast enhanced CT in all cases. None of the cases exhibited clinical regression. But three of them showed tumor regression around the IFN-β injected cavity, although the other part of the tumor remained progressive. These results suggested that direct tumorddal effects of IFN-β was exhibited to recurrent malignant gliomas, and local injection of IFN-β is so useful that should be used from the initial stage in addition to its intravenous use. There should be some strategic ideas to overcome ACNU resistance when reused. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
ja |
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出版者 |
琉球大学医学部 |
出版者 |
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言語 |
en |
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出版者 |
Faculty of Medicine, University of the Ryukyus |
言語 |
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言語 |
jpn |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0289-1530 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN10027430 |
収録物名 |
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言語 |
ja |
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収録物名 |
琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal |
書誌情報 |
巻 11,
号 3-4,
p. 131-140,
発行日 1991
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