{"_buckets": {"deposit": "c1604366-ad8b-433e-a5bf-1b01fae82713"}, "_deposit": {"id": "2015793", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2015793"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02015793", "sets": ["1642838242511", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[\u539f\u8457\uff3d\u518d\u767a\u60aa\u6027\u30b0\u30ea\u30aa-\u30de\u306b\u5bfe\u3059\u308bIFN-\u03b2\u5c40\u6240\u6295\u4e0e\u3068ACNU\u52d5\u6ce8\u7642\u6cd5\u306e\u8a66\u307f", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Combined Treatment of Local Injection IFN-\u03b2 and Intracarotid Injection of ACNU to Recurrent Malignant Gliomas", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4ef2\u5b97\u6839, \u9032", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u516d\u5ddd, \u4e8c\u90ce", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u826f, \u82f1\u4e00", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u9298\u82c5, \u664b", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u77f3\u5ddd, \u6cf0\u6210", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u4e45\u7530, \u5747", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Nakasone, Susumu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mukawa, Jiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takara, Eiichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mekaru, Susumu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Yasunari", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kuda, Hitoshi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Five cases of recurrent malignant gliomas were treated with local injection of interferon- \u03b2combined with intracarotid injection of 1-(4-amino 2methy1-5-pyrimidinyl)methy1 -3-(2-chlor\u221dthy1)-3-nitrosourea hydrochloride(ACNU). All patients had been already treated with intravenous injection of IFN-\u03b2 and/or ACNU as well as conventional radiotherapy after surgery. IFN-\u03b2(3\u00d710^6 IU, 3 times a week) was locally injected through a catheter placed into tumor-removed cavity. ACNU (100mg/6weeks) was injected into the carotid artery following osmotic blood brain barrier modification produced by arterial injetion of 20% 200ml mannitol. Multiple intracranial lesions were checked with contrast enhanced CT in all cases. None of the cases exhibited clinical regression. But three of them showed tumor regression around the IFN-\u03b2 injected cavity, although the other part of the tumor remained progressive. These results suggested that direct tumorddal effects of IFN-\u03b2 was exhibited to recurrent malignant gliomas, and local injection of IFN-\u03b2 is so useful that should be used from the initial stage in addition to its intravenous use. There should be some strategic ideas to overcome ACNU resistance when reused.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u5927\u5b66\u533b\u5b66\u90e8"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Faculty of Medicine, University of the Ryukyus"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10027430"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u5927\u5b66\u533b\u5b66\u4f1a\u96d1\u8a8c : \u533b\u5b66\u90e8\u7d00\u8981 = Ryukyu medical journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "140", "bibliographicPageStart": "131", "bibliographicVolumeNumber": "11"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v11p131.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2015793/files/v11p131.pdf"}, "version_id": "a59693b5-34df-48fa-bcf6-27ae3f68e6d4"}]}, "item_title": "[\u539f\u8457\uff3d\u518d\u767a\u60aa\u6027\u30b0\u30ea\u30aa-\u30de\u306b\u5bfe\u3059\u308bIFN-\u03b2\u5c40\u6240\u6295\u4e0e\u3068ACNU\u52d5\u6ce8\u7642\u6cd5\u306e\u8a66\u307f", "item_type_id": "15", "owner": "1", "path": ["1642838242511", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002015793", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-06-30"}, "publish_date": "2010-06-30", "publish_status": "0", "recid": "2015793", "relation": {}, "relation_version_is_last": true, "title": ["[\u539f\u8457\uff3d\u518d\u767a\u60aa\u6027\u30b0\u30ea\u30aa-\u30de\u306b\u5bfe\u3059\u308bIFN-\u03b2\u5c40\u6240\u6295\u4e0e\u3068ACNU\u52d5\u6ce8\u7642\u6cd5\u306e\u8a66\u307f"], "weko_shared_id": -1}