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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 13巻2号
  1. 部局別インデックス
  2. その他

[原著]Thy.1^- Bone Marrow Cells Passed through Nylon Wool Can Augment the Generation of Cytotoxic T Lymphocytes (CTL) with Preference for the X-Chromosome-Linked Gene Product in Primary Cultures in vitro

http://hdl.handle.net/20.500.12000/0002015856
http://hdl.handle.net/20.500.12000/0002015856
aded30a9-5670-4e06-a761-bde7557aaa11
名前 / ファイル ライセンス アクション
v13p133.pdf v13p133.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Thy.1^- Bone Marrow Cells Passed through Nylon Wool Can Augment the Generation of Cytotoxic T Lymphocytes (CTL) with Preference for the X-Chromosome-Linked Gene Product in Primary Cultures in vitro
言語 ja
作成者 Tanabe, Masao J

× Tanabe, Masao J

en Tanabe, Masao J

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 X-chromosome
言語 en
主題Scheme Other
主題 minor histocompatibility antigen
言語 en
主題Scheme Other
主題 cytotoxic T lymphocytes
言語 en
主題Scheme Other
主題 bone marrow cells
内容記述
内容記述タイプ Other
内容記述 Thy.1^- bone marrow cells passed through nylon wool (NW-BM cell) helped to induce the cytotoxic T lymphocytes (CTL) specific for allogeneic major histocompatibility complex (MHC) antigens in vitro as previously reported. In this report we studied whether they could also help to induce the CTL specific to minor histocompatibility (mH) antigens. When a limited number of responder lymph node (LN) cells and an excess of helper NW-BM cells from Balb/c (H-2^d) mice were cultured with stimulator spleen cells from B10D2 mice (H-2^d), the CTL specific for mH antigens restricted to self MHC were easily induced in primary cultures in vitro. These CTL killed only B10D2 target cells but not DBA/2 (H-2^d) which had some mH antigens in common with B10D2. Genetic analysis showed that these CTL had a strict preference for X-chromosome linked gene products (Xir antigen). When responder LN cells and NW-BM cells from Balb/c mice were replaced by those from DBA/2 mice, the same results were obtained. As the CTL specific to the Xir antigen was also induced either with (B10BRxBalb/c) F1 male anti (Balb/CXB10BR) Fl male or with a reciprocal combination, stimulation across the sex chromosomes was necessary and sufficient to induce these CTL. Stimulation across other mH antigens derived from autosomes was not required as the trans-activating bystander. This report suggests that the Xir antigen has a role in immune regulation, because non-self Xir antigen is the only stimulus in this culture system.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 13, 号 2, p. 133-145
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