| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2010-07-02 |
| タイトル |
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|
タイトル |
[原著］Effects of Insulin-induced Hypoglycemia on Cerebrovascular Permeability in Diabetic Rats |
|
言語 |
ja |
| 作成者 |
Tanaka, Hideaki
Murakami, Keiji
Mimura, Goro
|
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
言語 |
ja |
|
権利情報 |
琉球医学会 |
| 主題 |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
cerebrovascular permeability |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
insulin-induced hypoglycemia |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
streptozotocin-diabetic rats |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Evans blue |
| 主題 |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
albumin tracer |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
We studied the effect of insulin-induced hypoglycemia in both normal and streptozotocin-diabetic rats with two different durations of diabetes : 3 months and 6 months. The study was carried out in order to investigate : (a) whether diabetes alters cerebrovascular permeability, (b) whether the alteration of cerebrovascular permeability is changed by insulin-induced hypoglycemia, and (c) the relationship between the duration of the diabetic state and blood-brain barrier permeability. Evans blue fluorescence was used as an albumin tracer. In the basal condition, diabetic rats showed a significant increase in cerebrovascular permeability compared with normal rats. Insulin-induced hypoglycemia significantly enhanced cerebrovascular permeability in both normal rats and diabetic rats. The 6-month diabetic rats demonstrated a significant increase in cerebrovascular permeability compared with the 3-month diabetic rats. In summary, insulin-induced hypoglyoemia was thus demonstrated to be associated with a significant increase of cerebrovascular permeability in diabetic rats in relation to the duration of their diabetic state. Although the clinical significance of the findings still remains unknown, the results suggest the possibility that a similar phenomenon might also occur in the brains of long-term diabetic patients with severe and prolonged hypoglycemia. |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
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出版者 |
琉球医学会 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Ryukyu Medical Association |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346888X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0289-1530 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10369445 |
| 収録物名 |
|
|
収録物名 |
琉球医学会誌 = Ryukyu Medical Journal |
|
言語 |
ja |
| 書誌情報 |
巻 12,
号 3,
p. 226-234,
発行日 1992
|
v12p226.pdf
