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[原著］The Effects of Ethanol or Toluene on Plasma Lipids, Essential Amino Acids and Fatty Infiltration of the Liver in Wistar Male Rats
http://hdl.handle.net/20.500.12000/0002015918
http://hdl.handle.net/20.500.12000/0002015918b27f3c77-d98c-4059-aece-bef78d27ccc2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v12p8.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2010-07-02 | |||||||
| タイトル | ||||||||
| タイトル | [原著］The Effects of Ethanol or Toluene on Plasma Lipids, Essential Amino Acids and Fatty Infiltration of the Liver in Wistar Male Rats | |||||||
| 言語 | ja | |||||||
| 作成者 |
Dominicus, Dalmas A. R.
× Dominicus, Dalmas A. R.
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 言語 | ja | |||||||
| 権利情報 | 琉球医学会 | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | ethanol | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | toluene | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | amino acids | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | lipids | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | fatty liver | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | To investigate the differenoe between the effect of alcohol (ethanol) and toluene on the plasma lipids, essential amino acids and fatty infiltration of the liver, a study was done for two months involving male wistar rats. Ethanol, 20 rats, divided into L1 (ethanol 2.5g/kg body wt), L2 (ethanol 1.25g/kg body wt) and PF, control, received isocaloric glucose and food equal to the amount taken by LI. Toluene, 20 rats, divided into 10 toluene exposed rats (Te) , 900 ppm of toluene vapour in the chamber and 10 control rats (Ce) , clean air in the chamber. Statistical analysis using Stundent's t test showed significant increase in body weight, plasma triglyceride levels, total cholesterol, high density lipoprotein (HDL) and essential amino adds caused by ethanol. Ethanol caused a significant inarease in the activity of AsT (aspartate aminotransferase) and AlT (alanine aminotransferase) and the ratio AsT/AlT. LI and L2 showed fatty infiltration of the liver, Sudan III histological staining technique. No significant differentce between L1 and L2. No effects caused on the body weight, plasma lipids, essential amino acids and AsT and AlT activities by toluene. Also toluene did not cause fatty liver in this study. From this study long terra alcohol ingestion, not toluene inhalation exposure, caused effects on the metabolism of plasma lipids, HDL and essential amino acids as well as the adverse effects on the liver structure (fatty infiltration) and AsT and AlT activities. Alcohol effects were dose independent (i. e ethanol 2.5 and 1.25 g/kg body wt did not produce different effects). | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 論文 | |||||||
| 出版者 | ||||||||
| 出版者 | 琉球医学会 | |||||||
| 言語 | ja | |||||||
| 出版者 | ||||||||
| 出版者 | Ryukyu Medical Association | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1346888X | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0289-1530 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN10369445 | |||||||
| 収録物名 | ||||||||
| 収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||
| 言語 | ja | |||||||
| 書誌情報 |
巻 12, 号 1, p. 8-21, 発行日 1991 |
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