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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 15巻3号
  1. 部局別インデックス
  2. その他

[総説]血小板異常を伴う血液疾患

http://hdl.handle.net/20.500.12000/0002015960
http://hdl.handle.net/20.500.12000/0002015960
b59636d7-5956-4afd-be85-712e62c822b5
名前 / ファイル ライセンス アクション
v15p107.pdf v15p107.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [総説]血小板異常を伴う血液疾患
言語 ja
作成者 野崎, 宏幸

× 野崎, 宏幸

ja 野崎, 宏幸

Nozaki, Hiroyuki

× Nozaki, Hiroyuki

en Nozaki, Hiroyuki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 platelet
言語 en
主題Scheme Other
主題 ITP
言語 en
主題Scheme Other
主題 TTP
言語 en
主題Scheme Other
主題 transfusion
言語 en
主題Scheme Other
主題 thrombasthenia
内容記述
内容記述タイプ Other
内容記述 Hemostatic disorders are classified as abnormalities of platelets, abnormalities of coagulation factors, and abnormalities of blood vessels. Platelets are derived from megakaryocytes in bone marrow. Adhesion, aggregation and release-reactions are major functions of platelets. Patients with platelet disorders have symptoms such as bruising or mucosal bleeding. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by platelet destruction due to an antiplatelet autoantibody. Corticosteroids are recommended as initial treatment in ITP patients. However, persistent response rates are not so high. Persistent complete and partial response rates were 14% and 34%, respectively in our study. Splenectomy results in a much higher cure rate than any medical regimen. In our study, splenectomy induced a stable complete response in 56% of ITP patients having no permanent unmaintained response to steroids. Immunosuppression, intravenous $ \gamma $-globulin, danazol, ascorbic acid, and intravenous methylprednisolone have been used in ITP patients who fail steroids and splenectomy. In our study, any ITP patients did not achieve normal platelet levels when treated with low dose of danazol or ascorbic acid, though long term ascorbic acid therapy appeared to be slightly effective in aged ITP patients. Thrombotic thrombocytopenic purpura (TTP) is a heterogenous clinical syndrome characterized by the pentad of thrombocytopenic purpura, hemolytic anemia, neurologic abnormalities, fever and renal dysfunction. The etiology of TTP is not fully clarified. The survival rate has increased to about 80% with the use of plasma exchange. In our experience, a TTP patient entered persistent remission by the treatment of splenectomy after plasma exchange. The patients with thrombocytopenia due to underproduction require platelet transfusions to control bleeding. In our previous study, 45% of patients with acute leukemia and 89% of patients with aplastic anemia developed alloimmunization due to leukocyte contamination in transfusion products. Therefore, reducing the level of leukocyte contamination is necessary. Thrombasthenia is now defined as a hemorrhagic diathesis associated with a prolonged bleeding time, a normal platelet count, and absent macroscopic platelet aggregation in response to ADP or other platelet agonists. The biochemical lesion responsible for the disorder is a deficiency of the platelet membrane glycoprotein IIb/IIIa complex. Bernard-Soulier syndrome and storage pool disease also belong to congenital qualitative platelet disorders. Many drugs affect platelet functions. Especially, aspirin inhibits platelets responses irreversibly by inactivation of the enzyme cyclooxygenase. Some patients with chronic myeloproliferative disorders have acquired qualitative platelet abnormalities.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 15, 号 3, p. 107-111, 発行日 1995
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