{"_buckets": {"deposit": "3b9b2446-e8d8-45a1-b218-ae54c5306627"}, "_deposit": {"id": "2016002", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016002"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016002", "sets": ["1642838208619", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[原著］Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakasone, Hiroki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sgkuawa, Hiroshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakayoshi, Tmofumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawakami, Yuko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kinjo, Fukunori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Saito, Atushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamashiro, Akiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakayoshi, Tmokuni", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ikema, Minoru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hirayama, Yoshikatsu", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "interferon alpha"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "liver cirrhosis"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "hepatitis type C"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients with liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "121", "bibliographicPageStart": "117", "bibliographicVolumeNumber": "16"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v16p117.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016002/files/v16p117.pdf"}, "version_id": "b0882217-5e64-459c-8f41-59cdf6b705a9"}]}, "item_title": "[原著］Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection", "item_type_id": "15", "owner": "1", "path": ["1642838208619", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016002", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016002", "relation": {}, "relation_version_is_last": true, "title": ["[原著］Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection"], "weko_shared_id": -1}