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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 16巻3号
  1. 部局別インデックス
  2. その他

[原著]Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection

http://hdl.handle.net/20.500.12000/0002016002
http://hdl.handle.net/20.500.12000/0002016002
2cd473a7-20e0-4390-9524-b628fc90e522
名前 / ファイル ライセンス アクション
v16p117.pdf v16p117.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection
言語 ja
作成者 Nakasone, Hiroki

× Nakasone, Hiroki

en Nakasone, Hiroki

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Sgkuawa, Hiroshi

× Sgkuawa, Hiroshi

en Sgkuawa, Hiroshi

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Nakayoshi, Tmofumi

× Nakayoshi, Tmofumi

en Nakayoshi, Tmofumi

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Kawakami, Yuko

× Kawakami, Yuko

en Kawakami, Yuko

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Kinjo, Fukunori

× Kinjo, Fukunori

en Kinjo, Fukunori

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Saito, Atushi

× Saito, Atushi

en Saito, Atushi

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Yamashiro, Akiko

× Yamashiro, Akiko

en Yamashiro, Akiko

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Nakayoshi, Tmokuni

× Nakayoshi, Tmokuni

en Nakayoshi, Tmokuni

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Ikema, Minoru

× Ikema, Minoru

en Ikema, Minoru

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Hirayama, Yoshikatsu

× Hirayama, Yoshikatsu

en Hirayama, Yoshikatsu

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 interferon alpha
主題
言語 en
主題Scheme Other
主題 liver cirrhosis
主題
言語 en
主題Scheme Other
主題 hepatitis type C
内容記述
内容記述タイプ Other
内容記述 The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients with liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 16, 号 3, p. 117-121, 発行日 1996
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