Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2010-07-02 |
タイトル |
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タイトル |
[原著]Studies on the effect of noise stress on immune response of mice |
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言語 |
ja |
作成者 |
Fong, Kun Fan
Zheng, KuiCheng
Todoriki, Hidemi
Ariizumi, Makoto
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
ja |
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権利情報 |
琉球医学会 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
noise stress |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
antibody response |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
lymphocyte subset |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
corticosteroid |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
T-cell lineage |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
The immune responses of mice exposed to noise stress 12 hours daily for 18 days was investigated. Immune responses were estimated by antibody production to sheep red blood cell (SRBC), lymphoproliferation response and relative change of lymphocyte subsets in the thymus and spleen, with reference to plasma corticosteroid and catecholamine levels. A decrease in antibody response to SRBC, with an increase of plasma corticosteroid levels and a decrease in total thymocyte number, were observed in mice challenged with SRBC on the 7th day of noise exposure. The antibody response, however, was enhanced over control levels in mice challenged on the 18th day, with a decrease in corticosteroid levels and an in crease in thymocyte number. The catecholamine level increased considerably after onset of the noise stress. A decrease of CD4/CD8 double negative cells, with a relative increase of CD4/CD8 double positive cells, was also observed in the thymus on day 3. Both CD4^+ and CD8^+ single positive cells also decreased significantly in the thymus. These results suggest that depression of T-cell differentiation lineage in the thymus occurred in the stressed mice. The relative number of CD4^+/CD8^- (helper type) lymphocytes decreased in the spleen of mice on the 3rd day of the noise stress. Changes in the relative population of the lymphocyte subset, however, recovered to nearly normal levels on the 18th day of the experiment. These results indicate that, although the immune responses were depressed tentatively in the early stages of noise exposure, noise stress might essentially enhance the immune responsiveness of mice. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
ja |
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出版者 |
琉球医学会 |
出版者 |
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言語 |
en |
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出版者 |
Ryukyu Medical Association |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346888X |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0289-1530 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN10369445 |
収録物名 |
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言語 |
ja |
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収録物名 |
琉球医学会誌 = Ryukyu Medical Journal |
書誌情報 |
巻 17,
号 4,
p. 189-197,
発行日 1997
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