{"_buckets": {"deposit": "20f641fd-3956-4ffc-beb3-fd44b3f71159"}, "_deposit": {"id": "2016122", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016122"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016122", "sets": ["1642838220226", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[総説］アミノ配糖体難聴遺伝学的背景ならびにその予防と治療の現状", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Updates in Aminoglycoside-induced deafness", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "東野, 哲也", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Tono, Tetsuya", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "aminoglycoside-induced deafness"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "mitochondrial mutation"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "genetic analysis"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "sensorineural hearing loss"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "cochlear implantation"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Recent genetic studies have shown that hereditary susceptibility to aminoglycoside antibiotics is caused by the 1555 A-\u003eG mitochondrial mutation. We found the 1555 A-\u003eG mutation in 5.9% (4/68) of postlingually deaf patients, and 50% (4/8) of aminoglycoside-induced deaf patients. All the patients developed bilateral profound hearing loss due to aminoglycosides, i.e., Streptomycin in 3 cases and lsepamicin sulfate in one case. The most characteristic clinical feature in patients with the 1555 mutation is that the pedigrees of the probands show a maternally inherited hearing loss. Genetic analysis of this mutation is clinically significant since any maternal relatives of the patient may have hypersensitivity to ammoglycosides. We have not seen any maternal relatives with a known history of no aminoglycoside exposure, suffere deafness as severe as the probands observed in this study, indicating that the avoidance of aminoglycosides is extremely important for them. Cochlear implantation is a valuable choice of therapy for the patient with the profound hearing loss caused by this mutation. The exellent auditory performance with a cochlear implant suggests that the hearing loss is primarily caused by insult to the cochlear tissue containing rich mitochondria, and not to the cochlear nerve and its central connections.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "83", "bibliographicPageStart": "79", "bibliographicVolumeNumber": "23"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v23p79.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016122/files/v23p79.pdf"}, "version_id": "cb6d16fc-6368-4db9-9076-d509a3620dc3"}]}, "item_title": "[総説］アミノ配糖体難聴遺伝学的背景ならびにその予防と治療の現状", "item_type_id": "15", "owner": "1", "path": ["1642838220226", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016122", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016122", "relation": {}, "relation_version_is_last": true, "title": ["[総説］アミノ配糖体難聴遺伝学的背景ならびにその予防と治療の現状"], "weko_shared_id": -1}