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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 23巻3号
  1. 部局別インデックス
  2. その他

[総説]アミノ配糖体難聴遺伝学的背景ならびにその予防と治療の現状

http://hdl.handle.net/20.500.12000/0002016122
http://hdl.handle.net/20.500.12000/0002016122
128be265-7043-4081-9deb-30295e16fa99
名前 / ファイル ライセンス アクション
v23p79.pdf v23p79.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [総説]アミノ配糖体難聴遺伝学的背景ならびにその予防と治療の現状
言語 ja
作成者 東野, 哲也

× 東野, 哲也

ja 東野, 哲也

Tono, Tetsuya

× Tono, Tetsuya

en Tono, Tetsuya

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 aminoglycoside-induced deafness
言語 en
主題Scheme Other
主題 mitochondrial mutation
言語 en
主題Scheme Other
主題 genetic analysis
言語 en
主題Scheme Other
主題 sensorineural hearing loss
言語 en
主題Scheme Other
主題 cochlear implantation
内容記述
内容記述タイプ Other
内容記述 Recent genetic studies have shown that hereditary susceptibility to aminoglycoside antibiotics is caused by the 1555 A->G mitochondrial mutation. We found the 1555 A->G mutation in 5.9% (4/68) of postlingually deaf patients, and 50% (4/8) of aminoglycoside-induced deaf patients. All the patients developed bilateral profound hearing loss due to aminoglycosides, i.e., Streptomycin in 3 cases and lsepamicin sulfate in one case. The most characteristic clinical feature in patients with the 1555 mutation is that the pedigrees of the probands show a maternally inherited hearing loss. Genetic analysis of this mutation is clinically significant since any maternal relatives of the patient may have hypersensitivity to ammoglycosides. We have not seen any maternal relatives with a known history of no aminoglycoside exposure, suffere deafness as severe as the probands observed in this study, indicating that the avoidance of aminoglycosides is extremely important for them. Cochlear implantation is a valuable choice of therapy for the patient with the profound hearing loss caused by this mutation. The exellent auditory performance with a cochlear implant suggests that the hearing loss is primarily caused by insult to the cochlear tissue containing rich mitochondria, and not to the cochlear nerve and its central connections.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 23, 号 3, p. 79-83, 発行日 2004
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