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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 22巻1-2号
  1. 部局別インデックス
  2. その他

[原著]高血圧病態における血管平滑筋イオンチャネルの変化

http://hdl.handle.net/20.500.12000/0002016154
http://hdl.handle.net/20.500.12000/0002016154
b98b4bdd-1f2a-4130-94e4-435befc22498
名前 / ファイル ライセンス アクション
v22p15.pdf v22p15.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]高血圧病態における血管平滑筋イオンチャネルの変化
言語 ja
タイトル
タイトル Alterations of ion channels in vascular smooth muscle cells in hypertension
言語 en
作成者 大屋, 祐輔

× 大屋, 祐輔

ja 大屋, 祐輔

Search repository
Ohya, Yusuke

× Ohya, Yusuke

en Ohya, Yusuke

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Ion channel
主題
言語 en
主題Scheme Other
主題 hypertension
主題
言語 en
主題Scheme Other
主題 vascular smooth muscle
主題
言語 en
主題Scheme Other
主題 artery
主題
言語 en
主題Scheme Other
主題 calcium channel
主題
言語 en
主題Scheme Other
主題 potassium channel
内容記述
内容記述タイプ Other
内容記述 In controlling the vascular tone, membrane potential and ion channels have a pivotal role in the regulation of membrane excitation and Ca^<2+> flux in vascular smooth muscle cells. The in vivo and in vitro measurements of membrane potentials have shown that the resting membrane potential is more depolarized, spontaneous electrical activity is more frequent, and responses to mechanical stimulation is more enhanced in the arteries of hypertensive model animals than in normotensive controls. In patch clamp experiments, L-type Ca^<2+> channel currents, BK_ca channel currents, and stretch activated cation currents are more enhanced, and K_v channel currents are more suppressed in arterial smooth muscle cells of spontaneous hypertensive rats (SHR) than in Wistar Kyoto rats. Alterations in L-type Ca^<2+> channels, K_v channels and stretch activated channels contributes to the enhanced electrical activities in SHR arteries, while those in BK_ca channels suppress the excitability. Understanding these alterations could facilitate the development of new strategies for managing hypertension and hypertensive vascular injuries.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 22, 号 1-2, p. 15-19, 発行日 2003
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