{"_buckets": {"deposit": "80f53487-4926-4b5a-8b73-ecf853fdedcd"}, "_deposit": {"id": "2016187", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016187"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016187", "sets": ["1642838216134", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[症例報告]遺伝子治療が抱える安全問題 : ウイルスベクターの安全性", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Safety problems for gene therapy : Safety issues of virus vector", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "関口, 恵史", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "石田, 昭彦", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "新垣, 榮", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "安澄, 文興", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Sekiguchi, Keishi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishida, Akihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Arakaki, Sakae", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yasuzumi, Fumioki", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "gene therapy"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "safety test"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "virus vector"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "replication competent virus (RCV)"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Gene therapy has made remarkable progress in recent years with revision of its guidelines in Europe and America. These guidelines deal with an extensive range of safety issues. Viruses used in gene delivery systems make up seventy percent of vectors and play an important role in gene therapy. However these viruses cause a lot of pathological problems. These problems need to be considered and tested. Tests for replication competent virus (RCV), proteins derived from vectors, undesirable immune response, etc. are recommended to be conducted using these guidelines. The test for RCV is necessary for safety measures. A lot can still be done in the development of gene therapy. The safety issues are discussed not only for medical concerns (e.g. safety test), but also for the operations of the manufacturer. These discussions may contribute to the quality of medicines and reagents. The guidelines just guides the general concept for gene therapy, therefore, it is desired that we should have more discussions on safety issues, and organize conferences between research institutes and the government.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "3", "bibliographicPageEnd": "148", "bibliographicPageStart": "145", "bibliographicVolumeNumber": "20"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v20p145.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016187/files/v20p145.pdf"}, "version_id": "b9c60706-ca76-4c22-a637-f3fde8fd3273"}]}, "item_title": "[症例報告]遺伝子治療が抱える安全問題 : ウイルスベクターの安全性", "item_type_id": "15", "owner": "1", "path": ["1642838216134", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016187", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016187", "relation": {}, "relation_version_is_last": true, "title": ["[症例報告]遺伝子治療が抱える安全問題 : ウイルスベクターの安全性"], "weko_shared_id": -1}