{"_buckets": {"deposit": "ba17c34a-c7b6-4219-b0a5-bcbb2883ab90"}, "_deposit": {"id": "2016189", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016189"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016189", "sets": ["1642838220226", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[\u7dcf\u8aac\uff3d\u30d1\u30eb\u30d7\u30ed\u9178\u306e\u85ac\u7269,\u4ee3\u8b1d\u52d5\u614b : \u50ac\u5947\u602a\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Pharmacokinetics and metabolism of valproate : In relation to prevention of valproate teratogenicity", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u8fd1\u85e4, \u6bc5", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Kondo, Tsuyoshi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "valproate"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "teratogenicity"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "polypharmacy"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "pharmacokinetics"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "metabolism"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Pharmacokinetics and metabolism of valproate (VPA) has been discussed in relation to the risk and prevention of VPA teratogenicity. Prospective epidemiological studies have shown that high VPA dosages (\u22671000 mg/day) and high VPA concentrations (\u2267 70$ \\mu $g/ml) together with VPA polypharmacy (especially coadministration with enzyme-inducing antiepileptic drugs) are regarded as clinical risk factors for increased VPA teratogenicity. An animal experiment has also shown that high peak concentration after single dosing of VPA during the early stage of pregnancy correlates well with the incidence of neural tube defects. All of these risk factors enhance metabolic conversion from VPA to its toxic metabolite, 2-propy1-4-pentenoic acid (4-en). On the other hand, the use of slow-release formulation of valproate (VPA-SR) results in reduced formation of 4-en as well as decreased diurnal fluctuations in VPA concentrations. These pharmacokinetic and metabolic alterations by using VPA-SR may be helpful in reducing VPA teratogenicity. We therefore recommend that high VPA dosages, high VPA concentrations and VPA polypharmacy should be avoided in epileptic women of childbearing age. Conventional VPA, when used in these subjects, should be replaced with VPA-SR before pregnancy to diminish the risk of VPA teratogenicity.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u533b\u5b66\u4f1a"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u533b\u5b66\u4f1a\u8a8c = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "3", "bibliographicPageEnd": "77", "bibliographicPageStart": "71", "bibliographicVolumeNumber": "23"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v23p71.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016189/files/v23p71.pdf"}, "version_id": "9c3d7f33-7aae-4ad6-84a7-260eb58d4aea"}]}, "item_title": "[\u7dcf\u8aac\uff3d\u30d1\u30eb\u30d7\u30ed\u9178\u306e\u85ac\u7269,\u4ee3\u8b1d\u52d5\u614b : \u50ac\u5947\u602a\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089", "item_type_id": "15", "owner": "1", "path": ["1642838220226", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016189", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016189", "relation": {}, "relation_version_is_last": true, "title": ["[\u7dcf\u8aac\uff3d\u30d1\u30eb\u30d7\u30ed\u9178\u306e\u85ac\u7269,\u4ee3\u8b1d\u52d5\u614b : \u50ac\u5947\u602a\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089"], "weko_shared_id": -1}