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[総説]Effects of acyclic retinoid on cell cycle progression and signal transduction
http://hdl.handle.net/20.500.12000/0002016198
http://hdl.handle.net/20.500.12000/0002016198abcbb4b2-63ef-4b4e-a1b2-c3e61b8bc05d
名前 / ファイル | ライセンス | アクション |
---|---|---|
v23p1.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||
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公開日 | 2010-07-02 | |||||||
タイトル | ||||||||
タイトル | [総説]Effects of acyclic retinoid on cell cycle progression and signal transduction | |||||||
言語 | ja | |||||||
作成者 |
Suzui, Masumi
× Suzui, Masumi
|
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アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
権利情報 | ||||||||
言語 | ja | |||||||
権利情報 | 琉球医学会 | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | acyclic retinoid | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | hepatoma | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | cell cycle control | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | nuclear retinoic acid receptor | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | chemoprevention | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Acyclic retinoid (ACR), a novel synthetic retinoid, can prevent the recurrence of hepatomas after surgical resection of primary tumors, but the molecular mechanisms by which ACR exerts anti-tumor effects are not known. In recent studies we found that growth inhibition of human hepatoma cells by ACR is associated with induction of p21^<CIP1> and inhibition of expression of cyclin D1. $ \beta $-Catenin stimulates cyclin D1 promoter activity through T cell factor (TCF) in the HepG2 human hepatoma cell line, and this activity is inhibited by ACR. We also found that ACR activates retinoic acid receptor $ \beta $ and induces transcriptional activation of p21^<CIP1> in human hepatoma and squamous cell carcinoma cells. These novel effects of ACR suggest that this agent might be useful in the chemoprevention and therapy of various malignancies. These studies and their implications are summarized and discussed in this article. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 論文 | |||||||
出版者 | ||||||||
言語 | ja | |||||||
出版者 | 琉球医学会 | |||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | Ryukyu Medical Association | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ | journal article | |||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
出版タイプ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1346888X | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0289-1530 | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AN10369445 | |||||||
収録物名 | ||||||||
言語 | ja | |||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||
書誌情報 |
巻 23, 号 1-2, p. 1-9 |