ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "69361b6c-1a76-498c-9d29-5887ba07c0ef"}, "_deposit": {"id": "2016219", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016219"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016219", "sets": ["1642838216682", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[総説]わが国の降圧薬の大規模臨床試験について : 施行上の問題点", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Large scale clinical trials for hypertension in Japan : obstacles in performing the trials", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "瀧下, 修一", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Takishita, Shuichi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "large scale clinical trial"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "hypertension"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "antihypertensive treatment"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Many large scale clinical trials which were almost exclusively carried out in the western countries have revealed reductions in morbidity and mortality of cardiovascular diseases by pharmacological antihypertensive treatment. Japanese people, however, have different characteristics in cardiovascular morbidity from those in the western countries. The results of these studies are not necessarily applicable to Japanese people. Moreover, the large scale clinical trials are limited in Japan. The Japanese Trial on the Efficacy of Antihypertensive Treatment in the Elderly (JATE) was the first large scale double blind trial using an inactive placebo in Japan. The aim was to evaluate effects of antihypertensive treatment with Ca antagonists on cardiovascular events in 2,000 elderly patients with mild hypertension. However, the study failed because of enrollment of only 329 patients over 3.5 years. On the other hand, open trials or postmarketing surveillance comparatively succeeded in enrolling large number of patients. After discontinuing the JATE study, we sent a questionnaire to 1,433 physicians who had participated in the study to survey their attitudes to the JATE study and large scale clinical trials. Seven hundred and seventy eight physicians returned the questionnaire (response rate: 54.3%). Reasons for poor enrollment of patients (% agree): use of inactive placebo 40, difficulty in obtaining informed consent 37, lack of participant\u0027s benefit 36, low trust of the general public in administration of pharmaceutical affairs 26, few patients meeting eligibility criteria 26, too busy to obtain informed consent 23. Reasons for difficulty in obtaining informed consent (% agree): lack of recognition of importance of large scale clinical trials in general public and mass media 50, use of inactive placebo 30. Necessity of performing the trials in Japan: yes 99%, no 1%. Circumstances in which large scale clinical trials could be successfully performed (% agree): sufficient recognition of importance of the trials in general public 78, sufficient support by government 62, presence of coordinators in the institutes participated 58, presence of participant\u0027s benefit 54, presence of physician\u0027s benefit 24. These results point out that physicians, government, general public, mass media and pharmaceutical companies should sufficiently recognize the importance and necessity of large scale clinical trials in Japan. This should become a national consensus. Furthermore, effective systems for performing successful trials should be constructed.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "4", "bibliographicPageEnd": "171", "bibliographicPageStart": "167", "bibliographicVolumeNumber": "20"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v20p167.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016219/files/v20p167.pdf"}, "version_id": "bb29467d-579e-4439-8d78-ede1dd7fd281"}]}, "item_title": "[総説]わが国の降圧薬の大規模臨床試験について : 施行上の問題点", "item_type_id": "15", "owner": "1", "path": ["1642838216682", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016219", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016219", "relation": {}, "relation_version_is_last": true, "title": ["[総説]わが国の降圧薬の大規模臨床試験について : 施行上の問題点"], "weko_shared_id": -1}
  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 20巻4号
  1. 部局別インデックス
  2. その他

[総説]わが国の降圧薬の大規模臨床試験について : 施行上の問題点

http://hdl.handle.net/20.500.12000/0002016219
http://hdl.handle.net/20.500.12000/0002016219
ee6072ad-db06-4c2a-910b-33a7b64408d3
名前 / ファイル ライセンス アクション
v20p167.pdf v20p167.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [総説]わが国の降圧薬の大規模臨床試験について : 施行上の問題点
言語 ja
タイトル
タイトル Large scale clinical trials for hypertension in Japan : obstacles in performing the trials
言語 en
作成者 瀧下, 修一

× 瀧下, 修一

ja 瀧下, 修一

Search repository
Takishita, Shuichi

× Takishita, Shuichi

en Takishita, Shuichi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 large scale clinical trial
主題
言語 en
主題Scheme Other
主題 hypertension
主題
言語 en
主題Scheme Other
主題 antihypertensive treatment
内容記述
内容記述タイプ Other
内容記述 Many large scale clinical trials which were almost exclusively carried out in the western countries have revealed reductions in morbidity and mortality of cardiovascular diseases by pharmacological antihypertensive treatment. Japanese people, however, have different characteristics in cardiovascular morbidity from those in the western countries. The results of these studies are not necessarily applicable to Japanese people. Moreover, the large scale clinical trials are limited in Japan. The Japanese Trial on the Efficacy of Antihypertensive Treatment in the Elderly (JATE) was the first large scale double blind trial using an inactive placebo in Japan. The aim was to evaluate effects of antihypertensive treatment with Ca antagonists on cardiovascular events in 2,000 elderly patients with mild hypertension. However, the study failed because of enrollment of only 329 patients over 3.5 years. On the other hand, open trials or postmarketing surveillance comparatively succeeded in enrolling large number of patients. After discontinuing the JATE study, we sent a questionnaire to 1,433 physicians who had participated in the study to survey their attitudes to the JATE study and large scale clinical trials. Seven hundred and seventy eight physicians returned the questionnaire (response rate: 54.3%). Reasons for poor enrollment of patients (% agree): use of inactive placebo 40, difficulty in obtaining informed consent 37, lack of participant's benefit 36, low trust of the general public in administration of pharmaceutical affairs 26, few patients meeting eligibility criteria 26, too busy to obtain informed consent 23. Reasons for difficulty in obtaining informed consent (% agree): lack of recognition of importance of large scale clinical trials in general public and mass media 50, use of inactive placebo 30. Necessity of performing the trials in Japan: yes 99%, no 1%. Circumstances in which large scale clinical trials could be successfully performed (% agree): sufficient recognition of importance of the trials in general public 78, sufficient support by government 62, presence of coordinators in the institutes participated 58, presence of participant's benefit 54, presence of physician's benefit 24. These results point out that physicians, government, general public, mass media and pharmaceutical companies should sufficiently recognize the importance and necessity of large scale clinical trials in Japan. This should become a national consensus. Furthermore, effective systems for performing successful trials should be constructed.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 20, 号 4, p. 167-171
戻る
0
views
See details
Views

Versions

Ver.1 2022-02-22 04:43:12.868879
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3