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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 30巻1-4号
  1. 部局別インデックス
  2. その他

[依頼総説]HPV infection and squamous differentiation of lung cancer cells among patients in Okinawa, Japan

http://hdl.handle.net/20.500.12000/0002016243
http://hdl.handle.net/20.500.12000/0002016243
90a2ba40-b2f5-4ae3-96b3-d2cf5ccdd316
名前 / ファイル ライセンス アクション
v30(1-4)p1.pdf v30(1-4)p1.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2012-12-10
タイトル
タイトル [依頼総説]HPV infection and squamous differentiation of lung cancer cells among patients in Okinawa, Japan
言語 ja
作成者 Kinjo, Takao

× Kinjo, Takao

en Kinjo, Takao

金城, 貴夫

× 金城, 貴夫

ja 金城, 貴夫

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 lung cancer
言語 en
主題Scheme Other
主題 Okinawa
言語 en
主題Scheme Other
主題 squamous cell carcinoma
言語 en
主題Scheme Other
主題 adenocarcinoma
言語 en
主題Scheme Other
主題 HPV
内容記述
内容記述タイプ Other
内容記述 We reviewed histopathological reports of lung cancer cases in Okinawa, Japan and found a strong association between human papillomavirus (HPV) infection and squamous differentiation of lung cancer cells. On the basis of these observations, we hypothesized that HPV infection induces squamous differentiation of adenocarcinoma cells. To prove our hypothesis and determine the molecular basis of the phenomenon, we conducted a series of in vitro and in vivo studies. Cultured adenocarcinoma cells were transfected with the entire HPV genome and the cells were injected into SCID mice to form tumors, which were used for subsequent histopathological and biochemical analyses. The HPV-transfected cells showed no tubular structure but solid proliferation with expression of squamous differentiation markers such as high molecular weight keratin and involucrin. In particular, cells expressing HPV E2, E6, and E7 genes exhibited more marked morphological changes with increased expression of squamous differentiation markers. These experiments demonstrated that HPV gene expression in adenocarcinoma cells induces squamous differentiation. Although the present studies are only preliminary analyses, our findings have identified a new and specific aspect of lung cancer in cases in Okinawa. More precise and thorough evaluations are required. Since the diseases in Okinawa are specific to mainland Japan, further investigations may lead to the discovery of new mechanisms of disease and thereby contribute to health promotion of people in Okinawa.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 30, 号 1-4, p. 1-11
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