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[依頼総説]HPV infection and squamous differentiation of lung cancer cells among patients in Okinawa, Japan
http://hdl.handle.net/20.500.12000/0002016243
http://hdl.handle.net/20.500.12000/000201624390a2ba40-b2f5-4ae3-96b3-d2cf5ccdd316
名前 / ファイル | ライセンス | アクション |
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v30(1-4)p1.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2012-12-10 | |||||||||
タイトル | ||||||||||
タイトル | [依頼総説]HPV infection and squamous differentiation of lung cancer cells among patients in Okinawa, Japan | |||||||||
言語 | ja | |||||||||
作成者 |
Kinjo, Takao
× Kinjo, Takao
× 金城, 貴夫
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | lung cancer | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Okinawa | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | squamous cell carcinoma | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | adenocarcinoma | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | HPV | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | We reviewed histopathological reports of lung cancer cases in Okinawa, Japan and found a strong association between human papillomavirus (HPV) infection and squamous differentiation of lung cancer cells. On the basis of these observations, we hypothesized that HPV infection induces squamous differentiation of adenocarcinoma cells. To prove our hypothesis and determine the molecular basis of the phenomenon, we conducted a series of in vitro and in vivo studies. Cultured adenocarcinoma cells were transfected with the entire HPV genome and the cells were injected into SCID mice to form tumors, which were used for subsequent histopathological and biochemical analyses. The HPV-transfected cells showed no tubular structure but solid proliferation with expression of squamous differentiation markers such as high molecular weight keratin and involucrin. In particular, cells expressing HPV E2, E6, and E7 genes exhibited more marked morphological changes with increased expression of squamous differentiation markers. These experiments demonstrated that HPV gene expression in adenocarcinoma cells induces squamous differentiation. Although the present studies are only preliminary analyses, our findings have identified a new and specific aspect of lung cancer in cases in Okinawa. More precise and thorough evaluations are required. Since the diseases in Okinawa are specific to mainland Japan, further investigations may lead to the discovery of new mechanisms of disease and thereby contribute to health promotion of people in Okinawa. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346-888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0289-1530 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 30, 号 1-4, p. 1-11 |